Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)
• CAS No.: 122710-21-8
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2922399090
• Mol file: 122710-21-8.mol

Synonyms:Acetophenone,2'-amino-4'-methyl- (5CI)

Chemical Property of Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)

Chemical Property:

• Melting Point: 55-56 °C
• Boiling Point: 165 °C(Press: 15 Torr)
• PKA: 2.43±0.10(Predicted)
• PSA: 43.09000
• Density: 1.069±0.06 g/cm3(Predicted)
• LogP: 2.36100
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

1-(2-Amino-4-methyl-phenyl)-ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)

There total 9 articles about Ethanone, 1-(2-amino-4-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-acetyl-5-methylphenyl)-4-methylbenzenesulfonamide (1438400-27-1) → 2’-amino-4’-methylacetophenone (122710-21-8)

Guidance literature:

N-(2-acetyl-5-methylphenyl)-4-methylbenzenesulfonamide; With sulfuric acid; at 0 - 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

With sodium hydrogencarbonate; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3cc41915k

Reference yield: 81.0%

methyllithium (917-54-4) + 4-methylanthranilic acid (2305-36-4) → 2’-amino-4’-methylacetophenone (122710-21-8)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 ℃; for 4h; Inert atmosphere;

Reference yield: 34.0%

methylmagnesium bromide (75-16-1) + 5-methyl-2-cyanoaniline (26830-96-6) → 2’-amino-4’-methylacetophenone (122710-21-8)

Guidance literature:

methylmagnesium bromide; 5-methyl-2-cyanoaniline; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Schlenk technique; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201606026

upstream raw materials:

3-Methylacetanilide

1-(4-methyl-2-nitrophenyl)ethan-1-one

methyllithium

4-methylanthranilic acid

Downstream raw materials:

7-methyl-8-nitro-4-phenoxy-cinnoline

acetic acid-(2-acetyl-5-methyl-4-nitro-anilide)

acetic acid-(6-acetyl-3-methyl-2,4-dinitro-anilide)

(S)-3,6-dimethylisobenzofuran-1(3H)-one

Refernces

• 1、 -. "AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS". Page/Page column 140. . Retrieved 2021/11/26.
• 2、 Li, Liping,Gao, Hui,Sun, Ming,Zhou, Zhi,Yi, Wei. "Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks". . p. 5473 - 5478. Retrieved 2020/07/14.