Technology Process of 3-hydroxy-1-(2-iodophenyl)-3-methylbutan-1-one
There total 3 articles about 3-hydroxy-1-(2-iodophenyl)-3-methylbutan-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
titanium tetrachloride;
In
dichloromethane;
at 0 ℃;
for 0.75h;
Inert atmosphere;
Sealed tube;
Cooling with ice;
DOI:10.1002/adsc.201300728
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium iodide; triethylamine / acetonitrile / 1.5 h / 20 °C / Inert atmosphere
2: titanium tetrachloride / dichloromethane / 0.75 h / 0 °C / Inert atmosphere; Sealed tube; Cooling with ice
With
titanium tetrachloride; triethylamine; sodium iodide;
In
dichloromethane; acetonitrile;
DOI:10.1002/adsc.201300728
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / acetonitrile / 0 °C / Inert atmosphere
1.2: 4.5 h / 0 - 20 °C / Inert atmosphere
2.1: sodium iodide; triethylamine / acetonitrile / 1.5 h / 20 °C / Inert atmosphere
3.1: titanium tetrachloride / dichloromethane / 0.75 h / 0 °C / Inert atmosphere; Sealed tube; Cooling with ice
With
titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; sodium iodide;
In
dichloromethane; acetonitrile;
DOI:10.1002/adsc.201300728
