4-(2,4-DIFLUORO-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-(2,4-DIFLUORO-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER
• CAS No.: 942475-04-9
• Molecular Formula: C₁₁H₁₀F₂O₃
• Molecular Weight: 228.195
• Mol file: 942475-04-9.mol

Synonyms:C₁₁H₁₀F₂O₃

Chemical Property of 4-(2,4-DIFLUORO-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 274.0±30.0 °C(Predicted)
• PKA: 10.17±0.46(Predicted)
• Density: 1.262±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

KM000179:4-(2,4-Difluoro-phenyl)-3-oxo-butyricacidmethylester 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2,4-DIFLUORO-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER

There total 2 articles about 4-(2,4-DIFLUORO-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methanol (67-56-1) + C10H8F2O3 → C11H10F2O3 (942475-04-9)

Guidance literature:

for 4h; Heating;

DOI:10.1016/j.bmcl.2007.03.098

Reference yield:

2,4-difluorophenylacetic acid (81228-09-3) → C11H10F2O3 (942475-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2; DMF / CH₂Cl₂

2: 2,4,6-collidine

3: 81 percent / 4 h / Heating

With 2,4,6-trimethyl-pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmcl.2007.03.098

Reference yield: 87.0%

C11H10F2O3 (942475-04-9) + L-phenylglycine amide (6485-52-5) → C19H18F2N2O3

Guidance literature:

With acetic acid; In methanol; at 40 ℃; for 2h;

DOI:10.1016/j.bmcl.2007.03.098

upstream raw materials:

methanol

2,4-difluorophenylacetic acid

Downstream raw materials:

C₁₉H₂₀F₂N₂O₃

3-tert-butoxycarbonylamino-4-(2,4-difluoro-phenyl)-butyric acid

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