Technology Process of 5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine
There total 5 articles about 5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate;
In
1,4-dioxane;
at 20 ℃;
for 16h;
Inert atmosphere;
Molecular sieve;
Heating;
DOI:10.1021/ol4030925
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium t-butanolate; DavePhos;
In
1,4-dioxane;
at 20 ℃;
for 16h;
Inert atmosphere;
Molecular sieve;
Heating;
DOI:10.1021/ol4030925
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere
2: potassium carbonate; [Rh(OH)(cod)]2 / water; 1,4-dioxane / 20 °C / Inert atmosphere; Heating
3: palladium diacetate; sodium t-butanolate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; DavePhos / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Molecular sieve; Heating
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; [Rh(OH)(cod)]2; palladium diacetate; potassium carbonate; caesium carbonate; sodium t-butanolate; DavePhos;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ol4030925