5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Base Information

Chemical Name:5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine
CAS No.:1512812-19-9
Molecular Formula:C₂₄H₂₀F₆N₂
Molecular Weight:450.427
Hs Code.:

Synonyms:5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

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Chemical Property of 5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

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Technology Process of 5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

There total 5 articles about 5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2038-57-5
3-Phenylpropan-1-amine

: C₁₅H₉Cl₂F₆N

: 1512812-19-9
5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; chloro(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere; Molecular sieve; Heating;
DOI:10.1021/ol4030925

Reference yield:

: 2038-57-5
3-Phenylpropan-1-amine

: 1512812-61-1
3-chloro-2-(2-chlorophenethyl)-5-(trifluoromethyl)pyridine

: 1512812-19-9
5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

: 1572039-14-5
C₂₃H₂₂ClF₃N₂

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium t-butanolate; DavePhos; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere; Molecular sieve; Heating;
DOI:10.1021/ol4030925

Reference yield:

: 75806-84-7
2-bromo-3-chloro-5-(trifluoromethyl)pyridine

: 1512812-19-9
5-(3-phenylpropyl)-3,8-bis(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

2: potassium carbonate; [Rh(OH)(cod)]2 / water; 1,4-dioxane / 20 °C / Inert atmosphere; Heating

3: palladium diacetate; sodium t-butanolate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; DavePhos / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere; Molecular sieve; Heating

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [Rh(OH)(cod)]2; palladium diacetate; potassium carbonate; caesium carbonate; sodium t-butanolate; DavePhos; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ol4030925