2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Base Information

Chemical Name:2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one
CAS No.:1300582-08-4
Molecular Formula:C₁₇H₁₂F₂O₂
Molecular Weight:286.278
Hs Code.:
DSSTox Substance ID:DTXSID001197670

Synonyms:SCHEMBL8856;QDAACWAODCOABJ-UHFFFAOYSA-N;DTXSID001197670;2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one;2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-1-benzopyran-4-one;1300582-08-4

Suppliers and Price of 2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:286.08053595
Heavy Atom Count:21
Complexity:446

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=C(C(=O)C2=C(O1)C=CC(=C2)F)C3=CC(=CC=C3)F

Technology Process of 2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

There total 4 articles about 2-Ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1300582-07-3
1-(5-fluoro-2-hydroxyphenyl)-2-(3-fluorophenyl)ethanone

: 123-62-6
propionic acid anhydride

: 1300582-08-4
2-ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: With triethylamine; In propionic acid anhydride; triethylamine; for 24h; Reflux;

Reference yield: 43.0%

: 1300582-08-4
2-ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: With (carboethoxy)-2-norbornene; palladium diacetate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; at 100 ℃; for 36h; Inert atmosphere;

Reference yield:

: 459-60-9
1-fluoro-4-methoxybenzene

: 1300582-08-4
2-ethyl-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 12 h / 0 - 20 °C

2.1: triethylamine / triethylamine; propionic acid anhydride / 24 h / Reflux

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; propionic acid anhydride; triethylamine;