4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

Base Information

Chemical Name:4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one
CAS No.:256419-44-0
Molecular Formula:C₄₀H₆₀N₂O₅Si₂
Molecular Weight:705.098
Hs Code.:

4-benzyl-5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

Synonyms:4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

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Chemical Property of 4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

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Technology Process of 4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

There total 8 articles about 4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 824-94-2
p-methoxybenzyl chloride

: 256419-39-3
4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

: 256419-44-0
4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

Guidance literature:: With tetrabutylammomium bromide; sodium hydride; sodium bromide; In dimethyl sulfoxide; at 4 ℃; for 12h;
DOI:10.1007/PL00010189

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 256419-44-0
4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / tetrahydrofuran; ethanol / 24 h / 60 °C

2: 86 percent / NaBH₄; LiCl / ethanol; tetrahydrofuran / 24 h / 20 °C

3: HCl / CH₂Cl₂; ethyl acetate / 2 h

4: imidazole / CH₂Cl₂ / 12 h / 20 °C

5: CH₂Cl₂ / 0.5 h

6: 70 percent / NaH; Bu₄NBr; NaBr / dimethylsulfoxide / 12 h / 4 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tetrabutylammomium bromide; sodium hydride; sodium bromide; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; 1: Ring cleavage / 2: Reduction / 3: deprotection / 4: silylation / 5: cyclocondensation / 6: Alkylation;
DOI:10.1007/PL00010189

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 256419-44-0
4-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-1,3-bis-(4-methoxy-benzyl)-tetrahydro-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / CH₂Cl₂ / 12 h / 20 °C

2: CH₂Cl₂ / 0.5 h

3: 70 percent / NaH; Bu₄NBr; NaBr / dimethylsulfoxide / 12 h / 4 °C

With 1H-imidazole; tetrabutylammomium bromide; sodium hydride; sodium bromide; In dichloromethane; dimethyl sulfoxide; 1: silylation / 2: cyclocondensation / 3: Alkylation;
DOI:10.1007/PL00010189