N-(2-Bromo-5-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2-Bromo-5-methoxyphenyl)acetamide
• CAS No.: 123027-99-6
• Molecular Formula: C9H10 Br N O2
• Molecular Weight: 244.088
• DSSTox Substance ID: DTXSID10560948
• Nikkaji Number: J258.222H
• Wikidata: Q82444604
• Mol file: 123027-99-6.mol

Synonyms:123027-99-6;N-(2-BROMO-5-METHOXYPHENYL)ACETAMIDE;2'-Bromo-5'-methoxyacetanilide;MFCD12923200;Acetamide, N-(2-bromo-5-methoxyphenyl)-;2-Bromo-5-methoxyacetanilide;SCHEMBL7360829;DTXSID10560948;LQVIAWMRGFIPFM-UHFFFAOYSA-N;N-acetyl-2-bromo-5-methoxyaniline;AC2476;AKOS011704561;AS-64009;SY038711;CS-0321152;A909767;2 inverted exclamation mark -Bromo-5 inverted exclamation mark -methoxyacetanilide

Chemical Property of N-(2-Bromo-5-methoxyphenyl)acetamide

Chemical Property:

• PSA: 41.82000
• LogP: 3.06560
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 242.98949
• Heavy Atom Count: 13
• Complexity: 187

Purity/Quality:

97% ^*data from raw suppliers

N-(2-Bromo-5-methoxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=CC(=C1)OC)Br

Technology Process of N-(2-Bromo-5-methoxyphenyl)acetamide

There total 6 articles about N-(2-Bromo-5-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-5-methoxyaniline (59557-92-5) + acetic anhydride (108-24-7) → N-(2-bromo-5-methoxyphenyl)ethanamide (123027-99-6)

Guidance literature:

With dmap; In chloroform; for 2h; Reflux;

DOI:10.1055/s-0039-1690759

Reference yield: 92.0%

2-bromo-5-methoxyaniline (59557-92-5) + acetic acid (64-19-7,77671-22-8) → N-(2-bromo-5-methoxyphenyl)ethanamide (123027-99-6)

Guidance literature:

With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 0 - 20 ℃; for 18h;

DOI:10.1002/ejoc.201901302

Reference yield:

2-bromo-5-methoxyaniline (59557-92-5) + acetyl chloride (75-36-5) → N-(2-bromo-5-methoxyphenyl)ethanamide (123027-99-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4039(02)00132-6

upstream raw materials:

2-bromo-5-methoxyaniline

acetic anhydride

acetyl chloride

4-bromo-3-nitroanizole

Downstream raw materials:

5-methoxy-2-styrylacetanilide

2-ethenyl-5-methoxyacetanilide

N-acetyl-2-pentyn-1-yl-5-methoxyaniline

N-acetyl-2-hexyn-1-yl-5-methoxyaniline