(S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

Base Information

Chemical Name:(S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide
CAS No.:1417556-87-6
Molecular Formula:C₂₉H₃₂N₆O₃
Molecular Weight:512.611
Hs Code.:

Synonyms:(S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

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Chemical Property of (S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

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Technology Process of (S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

There total 10 articles about (S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1417557-05-1
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

: 1417557-08-4
2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetic acid

: 1417556-87-6
(S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 6639-87-8
6-nitroquinoxaline

: 1417556-87-6
(S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / methanol / 2 h / 0 - 20 °C

2.1: sodium methylate / methanol / 50 °C

2.2: 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 2 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrazine hydrate; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 99-56-9
4-Nitrophenylene-1,2-diamine

: 1417556-87-6
(S)-2-(2-(3-cyclopropyl-4-(2-hydroxyethyl)-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenyl-N-(quinoxalin-6-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water / 2 h / 100 °C / Inert atmosphere

2.1: hydrazine hydrate / methanol / 2 h / 0 - 20 °C

3.1: sodium methylate / methanol / 50 °C

3.2: 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 2 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrazine hydrate; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water;