Technology Process of (R)-5-[(Z)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-7-((4R,5R)-5-decyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hept-4-enyl]-dihydro-furan-2-one
There total 19 articles about (R)-5-[(Z)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-7-((4R,5R)-5-decyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hept-4-enyl]-dihydro-furan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: AD-mix-α, methanesulfonamide / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
2: 1.) aq. KOH, 2.) aq. HCl / 1.) MeOH
3: TsOH / CH2Cl2 / 1 h
4: imidazole / dimethylformamide / 16 h / Ambient temperature
5: H2 / Pd/C (10percent) / methanol; propionic acid / 24 h
6: PCC, celite / CH2Cl2 / 2 h
7: 1.) KN(SiMe3)2 / 1.) -78 deg C, 2 h, 2.) THF-HMPA, -78 deg C -> r.t., 16 h
With
1H-imidazole; hydrogenchloride; potassium hydroxide; AD-mix-α; methanesulfonamide; Celite; hydrogen; potassium hexamethylsilazane; toluene-4-sulfonic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; dichloromethane; water; propionic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo961286m
- Guidance literature:
-
Multi-step reaction with 4 steps
1: imidazole / dimethylformamide / 16 h / Ambient temperature
2: H2 / Pd/C (10percent) / methanol; propionic acid / 24 h
3: PCC, celite / CH2Cl2 / 2 h
4: 1.) KN(SiMe3)2 / 1.) -78 deg C, 2 h, 2.) THF-HMPA, -78 deg C -> r.t., 16 h
With
1H-imidazole; Celite; hydrogen; potassium hexamethylsilazane; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; dichloromethane; propionic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo961286m
- Guidance literature:
-
Multi-step reaction with 4 steps
1: imidazole / dimethylformamide / 16 h / Ambient temperature
2: H2 / Pd/C (10percent) / methanol; propionic acid / 24 h
3: PCC, celite / CH2Cl2 / 2 h
4: 1.) KN(SiMe3)2 / 1.) -78 deg C, 2 h, 2.) THF-HMPA, -78 deg C -> r.t., 16 h
With
1H-imidazole; Celite; hydrogen; potassium hexamethylsilazane; pyridinium chlorochromate;
palladium on activated charcoal;
In
methanol; dichloromethane; propionic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo961286m
