1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

Base Information

Chemical Name:1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene
CAS No.:481725-11-5
Molecular Formula:C₁₈H₃₁BrO₃SSi
Molecular Weight:435.498
Hs Code.:

Synonyms:1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

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Chemical Property of 1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

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Technology Process of 1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

There total 6 articles about 1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 481725-13-7
1-bromo-3-methoxy-4-propoxy-5-(2'-hydroxyethanesulfanyl)benzene

: 481725-11-5
1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0957-4166(02)00334-8

Reference yield:

: 5438-36-8
5-iodovaniline

: 481725-11-5
1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / cesium carbonate / dimethylformamide / 2 h / 50 °C

2: 91 percent / 2-methyl-2-butene; aq. sodium chlorite; NaH₂PO₄ / 2-methyl-propan-2-ol / 4 h / 20 °C

3: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

4: 1.6 g / 2-mercaptopyridine oxide sodium salt; BrCCl₃; AIBN / 0.08 h / Heating

5: 77 percent / copper bronze / dimethylformamide / 20 h / 100 °C

6: 92 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); Bromotrichloromethane; 2-mercaptopyridine-1-oxide sodium salt; copper; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0957-4166(02)00334-8

Reference yield:

: 106331-89-9
3-methoxy-4-n-propyloxy-5-iodobenzaldehyde

: 481725-11-5
1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / 2-methyl-2-butene; aq. sodium chlorite; NaH₂PO₄ / 2-methyl-propan-2-ol / 4 h / 20 °C

2: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

3: 1.6 g / 2-mercaptopyridine oxide sodium salt; BrCCl₃; AIBN / 0.08 h / Heating

4: 77 percent / copper bronze / dimethylformamide / 20 h / 100 °C

5: 92 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); Bromotrichloromethane; 2-mercaptopyridine-1-oxide sodium salt; copper; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0957-4166(02)00334-8