N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester

Base Information

• Chemical Name: N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester
• CAS No.: 618452-91-8
• Molecular Formula: C₃₆H₄₃N₅O₅S
• Molecular Weight: 657.834

Synonyms:N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester

Chemical Property of N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester

There total 1 articles about N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

N-(toluene-4-sulfonyl)-L-prolyl-O-(trifluoromethanesulfonyl)-L-tyrosine tert-butyl ester + 2-(piperazin-1-yl)benzonitrile (111373-03-6) → N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester (618452-91-8)

Guidance literature:

With caesium carbonate; johnphos; palladium diacetate; In tetrahydrofuran; at 60 ℃; for 4h;

DOI:10.1016/j.bmcl.2007.12.014

Reference yield: 71.0%

N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine tert-butyl ester (618452-91-8) → N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine (618447-98-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2007.12.014

upstream raw materials:

2-(piperazin-1-yl)benzonitrile

Downstream raw materials:

N-(toluene-4-sulfonyl)-L-prolyl-4-(4-(2-cyanophenyl)piperazin-1-yl)-L-phenylalanine

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