3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one

Base Information

• Chemical Name: 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one
• CAS No.: 637358-03-3
• Molecular Formula: C₁₁H₆FN₃OS₂
• Molecular Weight: 279.319

Synonyms:3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one

Chemical Property of 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one

There total 2 articles about 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

orthoformic acid triethyl ester (122-51-0) + 4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione (637358-02-2) → 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one (637358-03-3)

Guidance literature:

With acetic anhydride; for 1h; Heating;

DOI:10.1002/ardp.200300734

Reference yield:

4-fluorophenyl isothiocyanate (1544-68-9) → 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one (637358-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / sulphur; Et₃N / ethanol / 1 h / Heating

2: 85 percent / acetic anhydride / 1 h / Heating

With acetic anhydride; sulfur; triethylamine; In ethanol;

DOI:10.1002/ardp.200300734

Reference yield: 80.0%

1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(N-2-chloroacethylamino)-propan-2-ol + 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one (637358-03-3) → N-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-2-(3-(4-fluorophenyl)-7-oxo-2-thioxo-3,7-dihydrothiazolo[4,5-d]pyrimidin-6(2H)-yl)acetamide

Guidance literature:

With potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 100 ℃; for 7h;

DOI:10.1016/j.molliq.2020.114662

upstream raw materials:

orthoformic acid triethyl ester

4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione

4-fluorophenyl isothiocyanate

Downstream raw materials:

3-(4-fluoro-phenyl)-7-mercapto-3H-thiazolo[4,5-d]pyrimidine-2-thione

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