Technology Process of (+)-(βR,2S)-β-Phenylspirodithiolan>-2-ethanamin
There total 5 articles about (+)-(βR,2S)-β-Phenylspirodithiolan>-2-ethanamin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2) 2 N HCl, H2O / 1) ether, 7 d, r.t., 2) CH2Cl2, 80 deg C
2: 58 percent / KOH / methanol / Ambient temperature
3: 45 percent / BF3*Et2O / CH2Cl2 / 0 °C
4: 79 percent / NH3, BuLi / tetrahydrofuran; hexane / 0.5 h / -78 deg C to r.t.
5: 96 percent / Na, Br2 / 0.5 h / 55 °C
6: 15percent KOH / ethanol / 1) r.t., overnight, 2) reflux, 5 h
With
hydrogenchloride; potassium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; ammonia; water; bromine; sodium;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / Na, Br2 / 0.5 h / 55 °C
2: 15percent KOH / ethanol / 1) r.t., overnight, 2) reflux, 5 h
With
potassium hydroxide; bromine; sodium;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 45 percent / BF3*Et2O / CH2Cl2 / 0 °C
2: 79 percent / NH3, BuLi / tetrahydrofuran; hexane / 0.5 h / -78 deg C to r.t.
3: 96 percent / Na, Br2 / 0.5 h / 55 °C
4: 15percent KOH / ethanol / 1) r.t., overnight, 2) reflux, 5 h
With
potassium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; ammonia; bromine; sodium;
In
tetrahydrofuran; ethanol; hexane; dichloromethane;
