(-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester

Base Information

• Chemical Name: (-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester
• CAS No.: 86661-27-0
• Molecular Formula: C₁₆H₂₀O₃
• Molecular Weight: 260.333
• Mol file: 86661-27-0.mol

Synonyms:(-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester

Chemical Property of (-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester

There total 13 articles about (-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

→ methyl β-phenyl-2-oxocyclohexanepropanoate (86661-27-0,64833-18-7)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; for 0.333333h; Ambient temperature;

DOI:10.1021/ja00073a017

Reference yield: 58.0%

dimethyl 2‐{(S)‐phenyl[(1S)‐2‐oxocyclohexyl]methyl}propanedioate (86661-23-6) → (-)-(3R,1'S)-3-(2-Oxocyclohexyl)-3-phenylpropansaeure-methylester (86661-27-0)

Guidance literature:

With potassium hydroxide; In methanol; Ambient temperature;

Reference yield: 57.0%

methanol (67-56-1) + 1-(1-Cyclohexen-1-yl)pyrrolidine (1125-99-1) + 2-cinnamoyl-1,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate (1380446-23-0) → methyl β-phenyl-2-oxocyclohexanepropanoate (86661-27-0,64833-18-7)

Guidance literature:

1-(1-Cyclohexen-1-yl)pyrrolidine; 2-cinnamoyl-1,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate; In acetonitrile; for 1h; Inert atmosphere;

With tetrafluoroboric acid; In diethyl ether; acetonitrile; for 0.166667h; Inert atmosphere;

methanol; With dmap; In diethyl ether; acetonitrile; for 0.5h; optical yield given as %de; Inert atmosphere;

DOI:10.1002/anie.201109042

upstream raw materials:

styrene

methanol

carbon monoxide

lithium 1-cyclohexenolate

Downstream raw materials:

(-)-(βR,2S)-β-Phenylspirodithiolan>-2-propansaeure-methylester

(+)-(βR,2S)-β-Phenylspirodithiolan>-2-ethanamin

(-)-(βR,2S)-β-Phenylspirodithiolan>-2-propionamid

(-)-(R)-β-Phenylcyclohexanethanamin