8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Base Information

Chemical Name:8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline
CAS No.:121963-10-8
Molecular Formula:C₁₉H₁₇F₃N₂O₂
Molecular Weight:362.351
Hs Code.:

Synonyms:8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Suppliers and Price of 8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

There total 3 articles about 8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 121963-09-5
6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

: 121963-10-8
8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Guidance literature:: With hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; at 45 ℃; for 0.116667h; under 2585.7 Torr;
DOI:10.1021/jm00128a010

Reference yield:

: 81358-81-8
4-methyl-5-hydroxy-6-methoxy-8-nitroquinoline

: 121963-10-8
8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / tetrabutylammonium hydroxide / chlorobenzene; H₂O / 120 h / 60 - 65 °C

2: 64 percent / H₂ / platinum oxide / tetrahydrofuran; ethanol / 0.12 h / 45 °C / 2585.7 Torr

With tetra(n-butyl)ammonium hydroxide; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; chlorobenzene;
DOI:10.1021/jm00128a010

Reference yield:

: 705-29-3
3-Trifluoromethylbenzyl chloride

: 121963-10-8
8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / tetrabutylammonium hydroxide / chlorobenzene; H₂O / 120 h / 60 - 65 °C

2: 64 percent / H₂ / platinum oxide / tetrahydrofuran; ethanol / 0.12 h / 45 °C / 2585.7 Torr

With tetra(n-butyl)ammonium hydroxide; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; chlorobenzene;
DOI:10.1021/jm00128a010