Ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate

Base Information

Chemical Name:Ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate
CAS No.:28831-36-9
Molecular Formula:C₁₉H₁₈N₂O₃S
Molecular Weight:354.43
Hs Code.:
DSSTox Substance ID:DTXSID101145777

Synonyms:28831-36-9;ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate;ethyl 2-[3-(2-methylphenyl)-4-oxoquinazolin-2-yl]sulfanylacetate;Ethyl 2-((4-oxo-3-(o-tolyl)-3,4-dihydroquinazolin-2-yl)thio)acetate;Acetic acid, 2-[[3,4-dihydro-3-(2-methylphenyl)-4-oxo-2-quinazolinyl]thio]-, ethyl ester;DQA;Oprea1_394462;Oprea1_654632;SCHEMBL12888170;DTXSID101145777;STL296612;AKOS000547509;(4-Oxo-3-o-tolyl-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetic acid ethyl ester;CS-0361358;EU-0076229;SR-01000475254;SR-01000475254-1;ethyl {[3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetate;Ethyl 2-[[3,4-dihydro-3-(2-methylphenyl)-4-oxo-2-quinazolinyl]thio]acetate;ethyl 2-{[3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetate

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Chemical Property of Ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:354.10381361
Heavy Atom Count:25
Complexity:537

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CSC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3C

Technology Process of Ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate

There total 5 articles about Ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 105-39-5
chloroacetic acid ethyl ester

: 37641-48-8
3-(o-methylphenyl)-2-thioquinazolin-4(3H)-one

: 28831-36-9
ethyl 2-((4-oxo-3-(o-tolyl)-3,4-dihydroquinazolin-2-yl)thio)acetate

Guidance literature:: With potassium carbonate; In acetone; for 12h; Reflux;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 28831-36-9
ethyl 2-((4-oxo-3-(o-tolyl)-3,4-dihydroquinazolin-2-yl)thio)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 10 h / Reflux

2: potassium carbonate / acetone / 12 h / Reflux

With potassium carbonate; potassium hydroxide; In methanol; acetone;

Reference yield:

: 95-53-4
o-toluidine

: 28831-36-9
ethyl 2-((4-oxo-3-(o-tolyl)-3,4-dihydroquinazolin-2-yl)thio)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 10 h / Reflux

2: potassium carbonate / acetone / 12 h / Reflux

With potassium carbonate; potassium hydroxide; In methanol; acetone;