Technology Process of 2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-[4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]ethanol
There total 11 articles about 2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-[4-dimethylamino-4-(3-fluorophenyl)cyclohexyl]ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine;
With
hydrogenchloride; water;
In
tetrahydrofuran;
at 20 - 50 ℃;
for 55h;
With
sodium hydroxide;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.75 h / 20 °C
1.2: 18 h / 60 °C
2.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C
4.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C
5.1: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C / Cooling with ice
6.1: tetrahydrofuran / 48 h / 20 °C / Cooling with ice; Inert atmosphere
7.1: hydrogenchloride; water / tetrahydrofuran / 55 h / 20 - 50 °C
With
1H-imidazole; hydrogenchloride; water; sodium hydride; calcium(II) trifluoromethanesulfonate;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dmap / tetrahydrofuran / 16 h / 20 °C / Cooling with ice
2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 1 h / 20 °C
2.2: 16 h / 20 °C / Cooling with ice
3.1: hydrogen bromide; acetic acid / 1 h / 20 °C
4.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C
5.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C
6.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C
7.1: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C / Cooling with ice
8.1: tetrahydrofuran / 48 h / 20 °C / Cooling with ice; Inert atmosphere
9.1: hydrogenchloride; water / tetrahydrofuran / 55 h / 20 - 50 °C
With
1H-imidazole; hydrogenchloride; dmap; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; calcium(II) trifluoromethanesulfonate; acetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
![[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine](/Databaselist/images/loading.webp)
