[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

Base Information

Chemical Name:[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine
CAS No.:1189555-55-2
Molecular Formula:C₃₉H₅₂FN₃O₃SSi
Molecular Weight:690.01
Hs Code.:

[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

Synonyms:[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

There total 10 articles about [4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189555-54-1
4-[2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-dimethylamino-cyclohexanecarbonitrile

: 17318-03-5
bromo(3-fluorophenyl)magnesium

: 1189555-55-2
[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 48h; Cooling with ice; Inert atmosphere;

Reference yield:

: 93245-98-8
1,4-dioxaspiro[4.5]decane-8-carbaldehyde

: 1189555-55-2
[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.75 h / 20 °C

1.2: 18 h / 60 °C

2.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

5.1: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C / Cooling with ice

6.1: tetrahydrofuran / 48 h / 20 °C / Cooling with ice; Inert atmosphere

With 1H-imidazole; hydrogenchloride; water; sodium hydride; calcium(II) trifluoromethanesulfonate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 16502-01-5
tetrahydrobetacarboline

: 1189555-55-2
[4-[2-(9-benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(tert-butyldimethylsilanyloxy)ethyl]-1-(3-fluorophenyl)cyclohexyl]dimethylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 1 h / 20 °C

2.2: 16 h / 20 °C / Cooling with ice

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C

4.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 20 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

7.1: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C / Cooling with ice

8.1: tetrahydrofuran / 48 h / 20 °C / Cooling with ice; Inert atmosphere

With 1H-imidazole; hydrogenchloride; dmap; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; calcium(II) trifluoromethanesulfonate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;