2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol

Base Information

Chemical Name:2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol
CAS No.:1189555-50-7
Molecular Formula:C₂₇H₃₂N₂O₅S
Molecular Weight:496.627
Hs Code.:

Synonyms:2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol

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Chemical Property of 2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol

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Technology Process of 2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol

There total 5 articles about 2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 9-Benzenesulfonyl-2,3,4,9-tetrahydro-1H-β-carboline

: 1189555-60-9
8-(oxiran-2-yl)-1,4-dioxaspiro[4.5]decane

: 1189555-50-7
2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol

Guidance literature:: With calcium(II) trifluoromethanesulfonate; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 16502-01-5
tetrahydrobetacarboline

: 1189555-50-7
2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 1 h / 20 °C

2.2: 16 h / 20 °C / Cooling with ice

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C

4.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

With dmap; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; calcium(II) trifluoromethanesulfonate; acetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 153874-43-2
benzyl 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

: 1189555-50-7
2-(9-Benzenesulfonyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-1-(1,4-dioxaspiro[4.5]dec-8-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 1 h / 20 °C

1.2: 16 h / 20 °C / Cooling with ice

2.1: hydrogen bromide; acetic acid / 1 h / 20 °C

3.1: calcium(II) trifluoromethanesulfonate / tetrahydrofuran / 48 h / 20 °C

With hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; calcium(II) trifluoromethanesulfonate; acetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane;