Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-fluorophenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

Base Information

Chemical Name:Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-fluorophenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-
CAS No.:123437-48-9
Molecular Formula:C26H20 F N3 O2
Molecular Weight:425.462
Hs Code.:
Mol file:123437-48-9.mol

Synonyms:Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-fluorophenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

Suppliers and Price of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-fluorophenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-fluorophenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

Chemical Property:

PSA：70.39000
LogP:4.71590

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-fluorophenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-

There total 10 articles about Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-fluorophenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: Acetic acid 4-((Z)-2-hydroxy-3-oxo-propenyl)-phenyl ester

: 196959-81-6
2-amino-5-(4-fluorophenyl)-3-phenylmethylpyrazine

: 123437-48-9
8-benzyl-6-(4-fluorophenyl)-2-(4-hydroxyphenylmethyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 80 ℃;
DOI:10.3987/COM-05-10351

Reference yield: 26.0%

: 196959-81-6
2-amino-5-(4-fluorophenyl)-3-phenylmethylpyrazine

: 625848-58-0
1,1-diethoxy-3-(4-hydroxyphenyl)-2-propan-2-one

: 123437-48-9
8-benzyl-6-(4-fluorophenyl)-2-(4-hydroxyphenylmethyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one

Guidance literature:: 2-amino-5-(4-fluorophenyl)-3-phenylmethylpyrazine; 1,1-diethoxy-3-(4-hydroxyphenyl)-2-propan-2-one; In ethanol; at 20 ℃; for 0.0833333h; Inert atmosphere;

With hydrogenchloride; In ethanol; at 80 ℃; Inert atmosphere;

Reference yield:

: 853941-51-2
5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

: 123437-48-9
8-benzyl-6-(4-fluorophenyl)-2-(4-hydroxyphenylmethyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / K₃PO₄ / Pd(PPh₃)4 / dioxane / 4 h / 80 °C

2: 38 percent / aq. HCl / dioxane; H₂O / 80 °C

With hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; 1: Suzuki-Miyaura coupling;
DOI:10.3987/COM-05-10351