853941-51-2

Upstream product

• 671240-60-1 C₁₈H₁₇N₃O₃S 
• 671240-61-2 5-N-(p-toluenesulfonyl)amide-6-benzyl-2-O-trifluoromethanesulfonyloxy-pyrazine 

Downstream Products

• 196959-81-6 2-amino-5-(4-fluorophenyl)-3-phenylmethylpyrazine 
• 70217-86-6 2-amino-3-benzyl-5-phenyl-pyrazine 
• 1268631-78-2 3-benzyl-5-(6-methoxynaphthalen-2-yl)pyrazin-2-amine 
• 1268631-81-7 (E)-3-benzyl-5-styrylpyrazin-2-amine 
• 1268631-79-3 3-benzyl-5-(biphenyl-4-yl)pyrazin-2-amine 
• 1268631-80-6 3-benzyl-5-(4-phenoxyphenyl)pyrazin-2-amine 
• 1268631-67-9 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate 
• 853941-57-8 8-benzyl-6-(4-fluorophenyl)-2-(4-hydroxybenzylidene)-imidazo[1,2-a]pyrazin-3(2H)-one 
• 1268631-70-4 8-benzyl-2-(4-hydroxybenzylidene)-6-phenylimidazo[1,2-a]-pyrazin-3(2H)-one 
• 1268631-69-1 2-amino-3-benzyl-5-ethynylpyrazine 
• 853941-58-9 8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one 
• 124469-80-3 8-benzyl-6-(N,N-dimethyl-4-aminophenyl)-2-(4-hydroxyphenylmethyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one 
• 123437-48-9 8-benzyl-6-(4-fluorophenyl)-2-(4-hydroxyphenylmethyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one 
• 853941-55-6 8-benzyl-6-phenylethynyl-2-(4-fluorophenylmethyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one 

Relevant academic research and scientific papers

Suzuki-Miyaura coupling for general synthesis of dehydrocoelenterazine applicable for 6-position analogs directing toward bioluminescence studies

Synthesis of coelenterazine analogs is in recent demand to supply more luminescent compounds with reasonable stability as substrate for the photoprotein manipulated in a living cells or particular organelle. There are limited methods for the synthesis of

Novel synthetic route of coelenterazines -2-:Synthesis of various dehydrocoelenterazine analogs

The novel synthetic route to introduce varioussubstituents into 5-position of coelenteramine is described. Difficulties, however, are observed in the attempted synthesis of some analogs having labile functional groups. This is due to the strong acid conc. H2SO4 after Suzuki-Miyaura coupling, so that the route was limited only to the synthesis for aminopyrazines having acid-stable functional groups. In this report, we describe alternative success in the deprotection of N-tosyl-animopyrazine triflate before the cross coupling; thus, we obtained the aminopyrazine triflate in high yield. This compound enables us to synthesize various coelenterazine analogs. This triflate was proven to be so important intermediate that the versatile synthesis for coelenterazine and dehydrocoelenterazine analogs was established through Suzuki-Miyaura or Sonogashira coupling.