(E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

Base Information

Chemical Name:(E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide
CAS No.:1572184-11-2
Molecular Formula:C₂₃H₂₅N₃O₃
Molecular Weight:391.47
Hs Code.:

Synonyms:(E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

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Chemical Property of (E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

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Technology Process of (E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

There total 5 articles about (E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1196-70-9
indole-6-carboxaldehyde

: 1572184-92-9
2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

: 1572184-11-2
(E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

Guidance literature:: In ethanol; for 16h; Reflux;

Reference yield:

: 15191-36-3
2-bromo-4,6-dimethylphenol

: 1572184-11-2
(E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 1 h / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C

3: caesium carbonate / acetonitrile / 16 h

4: ethanol / 16 h / Reflux

5: ethanol / 16 h / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; sodium carbonate; caesium carbonate; In tetrahydrofuran; methanol; ethanol; acetonitrile;

Reference yield:

: 1572185-39-7
2-(furan-3-yl)-4,6-dimethylphenol

: 1572184-11-2
(E)-N’-((1H-indol-6-yl)methylene)-2-(2,4-dimethyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C

2: caesium carbonate / acetonitrile / 16 h

3: ethanol / 16 h / Reflux

4: ethanol / 16 h / Reflux

With palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; ethanol; acetonitrile;