Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)

Base Information

Chemical Name:Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)
CAS No.:123464-89-1
Molecular Formula:C₁₄H₁₇ClN₂O*ClH
Molecular Weight:301.216
Hs Code.:
UNII:810P1694K2
DSSTox Substance ID:DTXSID801017103
Wikipedia:PNU-282,987
Wikidata:Q7119896
ChEMBL ID:CHEMBL554984
Mol file:123464-89-1.mol

Synonyms:N-((3R)-1-Azabicyclo(2.2.2)oct-3-yl)-4-chlorobenzamide hydrochloride;PNU 282987;PNU-282987;PNU282987

Suppliers and Price of Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PNU 282987
10mg
$ 409.00

TRC
PNU282987
250mg
$ 495.00

Tocris
PNU282987 ≥98%(HPLC)
50
$ 634.00

Tocris
PNU282987 ≥98%(HPLC)
10
$ 151.00

Sigma-Aldrich
PNU 282987 - CAS 123464-89-1 - Calbiochem
0001
$ 140.00

Sigma-Aldrich
PNU 282987 - CAS 123464-89-1 - Calbiochem
5052780001
$ 135.00

DC Chemicals
PNU282987 >98%
1 g
$ 1400.00

Crysdot
PNU-282987 98+%
100mg
$ 418.00

Crysdot
PNU-282987 98+%
50mg
$ 228.00

ChemScene
PNU-282987 99.70%
100mg
$ 528.00

Total 49 raw suppliers

Chemical Property of Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:240-242℃
Refractive Index:1.612
Boiling Point:431.5°Cat760mmHg
Flash Point:214.8°C
PSA：32.34000
Density:1.27g/cm³
LogP:2.49280
Storage Temp.:Store at RT
Solubility.:Soluble in DMSO (up to 25 mg/ml)
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:300.0796186
Heavy Atom Count:19
Complexity:307

Purity/Quality:

99%, ^*data from raw suppliers

PNU 282987 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl.Cl
Isomeric SMILES:C1CN2CCC1[C@H](C2)NC(=O)C3=CC=C(C=C3)Cl.Cl
Description PNU 282987 (CAS 123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki?= 26 nM).1? The?a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimer’s, Parkinson’s, schizophrenia, and attention deficit disorders – agonism of this receptor with PNU 282987 has shown potential to ameliorate these deficits.2-5
Uses PNU 282987 is used as an activator of α-7 nicotinic acetylcholine receptor.

Technology Process of Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1)

There total 5 articles about Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%