6-Methoxy-3-methylpicolinaldehyde

Base Information

• Chemical Name: 6-Methoxy-3-methylpicolinaldehyde
• CAS No.: 123506-64-9
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• European Community (EC) Number: 867-193-9
• DSSTox Substance ID: DTXSID00560957
• Nikkaji Number: J273.989E
• Wikidata: Q72490705
• Mol file: 123506-64-9.mol

Synonyms:6-Methoxy-3-methylpicolinaldehyde;123506-64-9;6-methoxy-3-methylpyridine-2-carbaldehyde;2-Pyridinecarboxaldehyde, 6-methoxy-3-methyl- (9CI);SCHEMBL2261210;DTXSID00560957;AKOS006307904;2-Pyridinecarboxaldehyde, 6-methoxy-3-methyl-;G75335;EN300-7690342;A890704;Z1198311271

Chemical Property of 6-Methoxy-3-methylpicolinaldehyde

Chemical Property:

• Melting Point: 52.4-54℃
• Boiling Point: 239℃
• PKA: 2.94±0.10(Predicted)
• Flash Point: 99℃
• PSA: 39.19000
• Density: 1.123
• LogP: 1.21110
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxy-3-methylpicolinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C(C=C1)OC)C=O

Technology Process of 6-Methoxy-3-methylpicolinaldehyde

There total 3 articles about 6-Methoxy-3-methylpicolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Dibromopyridine (626-05-1) → 6-Methoxy-3-methyl-2-pyridinealdehyde (123506-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / methanol / 25 h / Heating

2: 1) n-BuLi / 1) THF, -78 deg C, 1 h, 2) -78 deg C, 30 min

With n-butyllithium; In methanol;

DOI:10.1021/jo00288a014

Reference yield:

6-bromo-2-methoxypyridine (40473-07-2) → 6-Methoxy-3-methyl-2-pyridinealdehyde (123506-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) THF, -78 deg C, 1 h, 2) -78 deg C, 30 min

With n-butyllithium;

DOI:10.1021/jo00288a014

Reference yield:

6-methoxypyridine-2-carbaldehyde (54221-96-4) + methyl iodide (74-88-4) → 6-Methoxy-3-methyl-2-pyridinealdehyde (123506-64-9) + 6-methoxy-5-methyl-2-pyridinecarboxaldehyde (123506-65-0)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jo00288a014

upstream raw materials:

6-methoxypyridine-2-carbaldehyde

methyl iodide

2,6-Dibromopyridine

6-bromo-2-methoxypyridine

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