Ethyl Imidazo[1,2-a]pyridine-3-carboxylate

Base Information

• Chemical Name: Ethyl Imidazo[1,2-a]pyridine-3-carboxylate
• CAS No.: 123531-52-2
• Molecular Formula: C10H10 N2 O2
• Molecular Weight: 190.2
• Hs Code.: 2933990090
• Mol file: 123531-52-2.mol

Synonyms:Ethyl Imidazo[1,2-a]pyridine-3-carboxylate

Chemical Property of Ethyl Imidazo[1,2-a]pyridine-3-carboxylate

Chemical Property:

• Refractive Index: 1.594
• PSA: 43.60000
• LogP: 1.51100
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethylimidazo[1,2-a]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl Imidazo[1,2-a]pyridine-3-carboxylate

There total 5 articles about Ethyl Imidazo[1,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-aminopyridine (504-29-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + ethyl bromoacetate (105-36-2) → imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester (123531-52-2)

Guidance literature:

2-aminopyridine; N,N-dimethyl-formamide dimethyl acetal; With sodium hydrogencarbonate; potassium iodide; In N,N-dimethyl-formamide; at 65 ℃; for 2h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 85 ℃; for 8h;

DOI:10.1016/j.ejmech.2021.113298

Reference yield:

N,N-dimethyl-N'-pyridin-2-yl-formamidine (57040-75-2) + ethyl bromoacetate (105-36-2) → imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester (123531-52-2)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 85 ℃; for 1h; Temperature; Solvent; Reagent/catalyst;

DOI:10.1007/s12039-018-1462-z

Reference yield:

2-aminopyridine (504-29-0) → imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester (123531-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 2 h / 65 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / 85 °C

With sodium hydrogencarbonate; In N,N-dimethyl-formamide;

DOI:10.1007/s12039-018-1462-z

upstream raw materials:

2-aminopyridine

ethyl 2-chloro-3-oxo-butyrate

N,N-dimethyl-N'-pyridin-2-yl-formamidine

ethyl bromoacetate

Downstream raw materials:

6-Imidazo[1,2-a]pyridin-3-yl-N-(2-phenoxy-ethyl)-[1,3,5]triazine-2,4-diamine

N-Benzyl-6-imidazo[1,2-a]pyridin-3-yl-[1,3,5]triazine-2,4-diamine

C₂₀H₂₀F₂N₄O

imidazo[1,2-a]pyridine-3-carboxylic acid