1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

Base Information

Chemical Name:1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide
CAS No.:1453175-13-7
Molecular Formula:C₂₃H₂₈N₆O₃S
Molecular Weight:468.58
Hs Code.:

Synonyms:1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

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Chemical Property of 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

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Technology Process of 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

There total 12 articles about 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172281-91-3,4983-39-5
4-(pyrrolidin-1-yl)piperidine hydrochloride

: 1453176-77-6
4-{[(1H-pyrazolo[3_,4-b]pyridine-5-carbonyl)amino]methyl}benzenesulfonyl chloride

: 1453175-13-7
1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 952182-02-4
1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid

: C₁₅H₂₃N₃O₂S

: 1453175-13-7
1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1016/j.bmcl.2013.08.074

Reference yield:

: 227617-15-4
4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

: 1453175-13-7
1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 3 h / 60 °C

2: triethylamine; hydrogen; 10 wt% Pd(OH)2 on carbon / tetrahydrofuran / 3 h / 20 °C

3: trifluoroacetic acid / 4 h / 80 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 24 h / 20 °C

5: chlorosulfonic acid / 6 h / 20 °C / Cooling with ice

6: triethylamine / dichloromethane / 24 h / 20 °C

With chlorosulfonic acid; 10 wt% Pd(OH)2 on carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane;