cis-4-(3-(Diethylamino)propynyl)-1,3-dimethyl-6-phenyl-3,4-piperidinediol

Base Information

Chemical Name:cis-4-(3-(Diethylamino)propynyl)-1,3-dimethyl-6-phenyl-3,4-piperidinediol
CAS No.:120729-82-0
Molecular Formula:C₂₀H₃₀N₂O₂
Molecular Weight:330.47
Hs Code.:
DSSTox Substance ID:DTXSID50152987
Wikidata:Q76279514
Mol file:120729-82-0.mol

Synonyms:BRN 3562979;3,4-Piperidinediol, 4-(3-(diethylamino)-1-propynyl)-1,3-dimethyl-6-phenyl-, (3-alpha,4-beta,6-beta)-;cis-4-(3-(Diethylamino)propynyl)-1,3-dimethyl-6-phenyl-3,4-piperidinediol;120729-82-0;DTXSID50152987;LS-115155

Suppliers and Price of cis-4-(3-(Diethylamino)propynyl)-1,3-dimethyl-6-phenyl-3,4-piperidinediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of cis-4-(3-(Diethylamino)propynyl)-1,3-dimethyl-6-phenyl-3,4-piperidinediol

Chemical Property:

Vapor Pressure:3.82E-09mmHg at 25°C
Boiling Point:457°C at 760 mmHg
Flash Point:209.7°C
Density:1.12g/cm³
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:330.230728204
Heavy Atom Count:24
Complexity:473

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CC#CC1(CC(N(CC1(C)O)C)C2=CC=CC=C2)O
Isomeric SMILES:CCN(CC)CC#C[C@@]1(C[C@H](N(C[C@]1(C)O)C)C2=CC=CC=C2)O

Technology Process of cis-4-(3-(Diethylamino)propynyl)-1,3-dimethyl-6-phenyl-3,4-piperidinediol

There total 2 articles about cis-4-(3-(Diethylamino)propynyl)-1,3-dimethyl-6-phenyl-3,4-piperidinediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 84687-60-5,84687-62-7,84714-91-0,98114-75-1
(3R,4S,6R)-4-Ethynyl-1,3-dimethyl-6-phenyl-piperidine-3,4-diol

: 109-89-7
diethylamine

: 120729-82-0
(3S,4R,6S)-4-(3-Diethylamino-prop-1-ynyl)-1,3-dimethyl-6-phenyl-piperidine-3,4-diol

Guidance literature:: With copper(I) chloride; In 1,4-dioxane; for 6h; Heating;
DOI:10.1007/BF00764463

Reference yield:

: 36106-49-7,52899-10-2,56029-53-9
3e-Hydroxy-1e,3a-dimethyl-6e-phenyl-4-piperidone

: 120729-82-0
(3S,4R,6S)-4-(3-Diethylamino-prop-1-ynyl)-1,3-dimethyl-6-phenyl-piperidine-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: liquid ammonia; diethyl ether / 1 h

2: 84 percent / Cu₂Cl₂ / dioxane / 6 h / Heating

With copper(I) chloride; In 1,4-dioxane; diethyl ether; ammonia;
DOI:10.1007/BF00764463