phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

Base Information

Chemical Name:phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate
CAS No.:1300089-35-3
Molecular Formula:C₂₃H₁₈FN₃O₂S
Molecular Weight:419.479
Hs Code.:

Synonyms:phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

Suppliers and Price of phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

There total 5 articles about phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 209985-45-5
[5-(4-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]carbamic acid benzyl ester

: 1300089-35-3
phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

Guidance literature:: With Lawessons reagent; In toluene; for 4h; Inert atmosphere; Reflux;

Reference yield:

: 124676-19-3
2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine

: 1300089-35-3
phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

2: ammonia / methanol / 1 h / 20 °C / Inert atmosphere

3: ammonium acetate; acetic acid / 24 h / 20 °C

4: Lawessons reagent / toluene / 4 h / Inert atmosphere; Reflux

With Lawessons reagent; dmap; ammonium acetate; ammonia; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene;

Reference yield:

: 3800-06-4
2-amino-4'-fluorobenzophenone

: 1300089-35-3
phenylmethyl [5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

2: ammonia / methanol / 1 h / 20 °C / Inert atmosphere

3: ammonium acetate; acetic acid / 24 h / 20 °C

4: Lawessons reagent / toluene / 4 h / Inert atmosphere; Reflux

With Lawessons reagent; dmap; ammonium acetate; ammonia; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene;