4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid

Base Information

Chemical Name:4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid
CAS No.:1454844-97-3
Molecular Formula:C₁₀H₁₅BO₅
Molecular Weight:226.037
Hs Code.:

Synonyms:4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid

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Chemical Property of 4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid

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Technology Process of 4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid

There total 3 articles about 4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121-43-7,63156-11-6
Trimethyl borate

: 1454845-07-8
1-bromo-4-methoxy-5-methoxymethoxy-2-methylbenzene

: 1454844-97-3
4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid

Guidance literature:: 1-bromo-4-methoxy-5-methoxymethoxy-2-methylbenzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm400719y

Reference yield:

: 93-51-6
2-Methoxy-4-methylphenol

: 1454844-97-3
4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 5 h / 0 °C

3.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

With N-Bromosuccinimide; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm400719y

Reference yield:

: 72791-83-4
2-methoxy-1-methoxymethoxy-4-methylbenzene

: 1454844-97-3
4-methoxy-5-methoxymethoxy-2-methylphenyl boronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 5 h / 0 °C

2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With N-Bromosuccinimide; tert.-butyl lithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm400719y