4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

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Chemical Name:4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid
CAS No.:1441755-68-5
Molecular Formula:C₂₉H₂₆Cl₂N₄O₄
Molecular Weight:565.456
Hs Code.:

Synonyms:4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

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Chemical Property of 4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

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Technology Process of 4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

There total 12 articles about 4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441755-76-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-68-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; water; at 20 ℃; for 20h;

Reference yield:

: 1441739-72-5
4-formyl-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-68-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

2.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 20 h / 20 °C

With lithium hydroxide monohydrate; triethylamine; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water;

Reference yield:

: 1441739-56-5
4-bromo-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-68-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

3.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

4.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 20 h / 20 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; tert-butyl alcohol; 1.1: |Suzuki Coupling;