Technology Process of benzyl (cis-exo)-N-[2-methyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]carbamate
There total 7 articles about benzyl (cis-exo)-N-[2-methyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
formaldehyd; benzyl (cis-exo)-N-[1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-5-yl]carbamate;
In
water; acetonitrile;
for 0.166667h;
Inert atmosphere;
With
water; sodium tris(acetoxy)borohydride;
In
acetonitrile;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid / dichloromethane / 0.5 h / Cooling with ice; Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 12 h / 20 - 30 °C
2.2: 20 - 30 °C
3.1: triethylamine / dichloromethane / 3 h / Inert atmosphere
4.1: hydrogenchloride / 1,4-dioxane; water / 12 h / 50 °C / Inert atmosphere
4.2: 20 - 30 °C / pH 2
5.1: acetonitrile; water / 0.17 h / Inert atmosphere
5.2: 2 h / Inert atmosphere
With
hydrogenchloride; hydrogen; acetic acid; triethylamine;
palladium 10% on activated carbon;
In
1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 12 h / 20 - 30 °C
1.2: 20 - 30 °C
2.1: triethylamine / dichloromethane / 3 h / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; water / 12 h / 50 °C / Inert atmosphere
3.2: 20 - 30 °C / pH 2
4.1: acetonitrile; water / 0.17 h / Inert atmosphere
4.2: 2 h / Inert atmosphere
With
hydrogenchloride; hydrogen; acetic acid; triethylamine;
palladium 10% on activated carbon;
In
1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
