methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate

Base Information

• Chemical Name: methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate
• CAS No.: 1612146-84-5
• Molecular Formula: C₁₉H₂₀O₈
• Molecular Weight: 376.363

Synonyms:methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate

Chemical Property of methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate

Chemical Property:

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Technology Process of methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate

There total 9 articles about methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methyl 6-hydroxybenzo[d][1,3]dioxole-5-carboxylate (82146-04-1) + 4-methoxy-2-O-methoxymethylbenzyl bromide (152955-15-2) → methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate (1612146-84-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h;

DOI:10.1002/ejoc.201301722

Reference yield:

4-methoxy-2-methoxymethoxy benzaldehyde (124555-63-1) → methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate (1612146-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 1 h / 20 °C

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 110 °C

With sodium tetrahydroborate; N-Bromosuccinimide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201301722

Reference yield:

6-methoxymethoxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester (422566-45-8) → methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate (1612146-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / toluene / 1 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 110 °C

With methanol; potassium carbonate; In N,N-dimethyl-formamide; toluene;

DOI:10.1002/ejoc.201301722

upstream raw materials:

6-methoxymethoxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester

methyl 6-hydroxybenzo[d][1,3]dioxole-5-carboxylate

4-methoxy-2-O-methoxymethylbenzyl bromide

2-Hydroxy-4-methoxybenzaldehyde

Downstream raw materials:

1-(6-hydroxybenzo[d][1,3]dioxol-5-yl)-2-[4-methoxy-2-(methoxymethoxy)phenyl]ethane-1,2-dione

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