(R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Base Information

Chemical Name:(R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline
CAS No.:1383456-31-2
Molecular Formula:C₃₀H₂₃ClN₂O₂S
Molecular Weight:511.044
Hs Code.:

Synonyms:(R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

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Chemical Property of (R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

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Technology Process of (R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

There total 4 articles about (R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59046-72-9
o-(phenylethynyl)benzaldehyde

: 1721-96-6
1-methyl-3-phenylisoquinoline

: 1383456-23-2
(R)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline

: 1383456-30-1
(R)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

: 1394324-93-6
(Z)-1-benzylidene-3-(phenylethynyl)-1,3-dihydroisobenzofuran

: (S)-1-(1H-indol-3-yl)-3-phenyl-2-tosyl-1,2-dihydroisoquinoline

: 1202458-12-5
1-methyl-3-phenylisoquinoline-2-oxide

: (S)-3-phenyl-1-(5-methoxy-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

: 1394324-92-5
phenyl(2-phenyl-3-(tributylstannyl)naphthalen-1-yl)methanone

: 1383456-32-3
(R)-3-phenyl-1-(1-methyl-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

: (S)-3-phenyl-1-(1-methyl-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

: 1383456-31-2
(R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

: (S)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

With pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c3cc47221c

Reference yield:

: 4-methyl-N-(2-(phenylethynyl)benzylidene)benzenesulfonamide

: 17422-33-2
6-chloroindole

: 1383456-31-2
(R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

: (S)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Guidance literature:: With Ag⁽¹⁺⁾*C₅₂H₆₀O₄P^(1-); In toluene; at 40 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Darkness;
DOI:10.1016/j.tet.2012.02.058

Reference yield:

: 536-74-3
phenylacetylene

: 1383456-31-2
(R)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

: (S)-3-phenyl-1-(6-chloro-1H-indol-3-yl)-2-tosyl-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

2: titanium(IV) tetraethanolate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: Ag⁽¹⁺⁾*C₅₂H₆₀O₄P^(1-) / toluene / 40 °C / Inert atmosphere; Darkness

With bis-triphenylphosphine-palladium(II) chloride; titanium(IV) tetraethanolate; copper(l) iodide; Ag⁽¹⁺⁾*C₅₂H₆₀O₄P^(1-); triethylamine; In tetrahydrofuran; toluene; 3: Friedel Crafts alkylation;
DOI:10.1016/j.tet.2012.02.058