N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide

Base Information

Chemical Name:N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide
CAS No.:1314141-30-4
Molecular Formula:C₂₃H₂₅N₃O₂S
Molecular Weight:407.536
Hs Code.:

Synonyms:N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide

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Chemical Property of N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide

Chemical Property:

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Technology Process of N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide

There total 5 articles about N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24782-43-2
ethyl 4-hydroxyquinoline-2-carboxylate

: 1314141-30-4
N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus(V) oxybromide / toluene; acetonitrile / 1.5 h / 75 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 16 h / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 90 °C

5: dimethyl sulfoxide / 3 h / 120 °C / Microwave

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; phosphorus(V) oxybromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: 1314141-22-4
PT-3214

: 5188-07-8
sodium thiomethoxide

: 1314141-30-4
N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide

Guidance literature:: In dimethyl sulfoxide; at 120 ℃; for 3h; Microwave;

Reference yield:

: 209003-46-3
4-bromoquinoline-2-carboxylic acid

: 1314141-30-4
N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(methylsulfanyl)pyridin-3-yl]methyl}quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 16 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 90 °C

3: dimethyl sulfoxide / 3 h / 120 °C / Microwave

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;