ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate

Base Information

Chemical Name:ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate
CAS No.:198064-38-9
Molecular Formula:C₁₈H₁₈ClN₃O₃
Molecular Weight:359.812
Hs Code.:

Synonyms:ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate

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Chemical Property of ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate

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Technology Process of ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate

There total 10 articles about ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-03-6
ethyl iodide

: 198064-11-8
3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionic acid

: 198064-38-9
ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 198064-38-9
ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / AlCl₃ / 2 h / 20 °C

2: 88 percent / Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / 12 h / Heating

4: 61.2 g / pyridine / tetrahydrofuran / 1 h / 20 °C

5: 79 percent / NH₄OAc; AcOH / 2 h / Heating

6: 73 percent / POCl₃; pyridine / 1.5 h / 125 °C

7: 96 percent / aq. NaOH / ethanol / 1 h / 20 °C

8: 84 percent / K₂CO₃ / dimethylformamide / 10 h / 120 - 130 °C

9: 90 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

With pyridine; sodium hydroxide; aluminium trichloride; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;
DOI:10.1248/cpb.51.565

Reference yield:

: 71354-29-5
methyl 5-(4-chlorophenyl)-5-oxopentanoate

: 198064-38-9
ethyl 3-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]propionate

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / Br₂ / CH₂Cl₂ / 20 °C

2: HCO₂Na / methanol / 12 h / Heating

3: 61.2 g / pyridine / tetrahydrofuran / 1 h / 20 °C

4: 79 percent / NH₄OAc; AcOH / 2 h / Heating

5: 73 percent / POCl₃; pyridine / 1.5 h / 125 °C

6: 96 percent / aq. NaOH / ethanol / 1 h / 20 °C

7: 84 percent / K₂CO₃ / dimethylformamide / 10 h / 120 - 130 °C

8: 90 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

With pyridine; sodium hydroxide; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.51.565