(1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

Base Information

Chemical Name:(1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol
CAS No.:1369768-85-3
Molecular Formula:C₁₃H₁₇FO₄
Molecular Weight:256.274
Hs Code.:

Synonyms:(1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

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Chemical Property of (1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

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Technology Process of (1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

There total 4 articles about (1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369768-84-2
(1S,5R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]-3-oxabicyclo[3.1.0]hexan-2-one

: 1369768-85-3
(1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

Guidance literature:: (1S,5R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]-3-oxabicyclo[3.1.0]hexan-2-one; With lithium borohydride; In tetrahydrofuran; methanol; at -30 - 35 ℃; for 15h;

With ammonium chloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1369768-83-1
2-[3-fluoro-4-(methoxymethoxy)phenyl]acetonitrile

: 1369768-85-3
(1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -15 °C

1.2: -15 - 35 °C

2.1: lithium borohydride / tetrahydrofuran; methanol / 15 h / -30 - 35 °C

With lithium borohydride; sodium hexamethyldisilazane; In tetrahydrofuran; methanol;

Reference yield:

: 949090-28-2
3-fluoro-4-methoxymethoxybenzaldehyde

: 1369768-85-3
(1S,2R)-1-[3-fluoro-4-(methoxymethoxy)phenyl]cyclopropane-1,2-dimethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 35 °C / Cooling with ice

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 14 h / 35 °C / Cooling with ice

2.2: 8 h / 80 - 100 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -15 °C

3.2: -15 - 35 °C

4.1: lithium borohydride / tetrahydrofuran; methanol / 15 h / -30 - 35 °C

With sodium tetrahydroborate; lithium borohydride; sodium hexamethyldisilazane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;