4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid

Base Information

Chemical Name:4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid
CAS No.:124281-65-8
Molecular Formula:C₁₁H₉NO₃
Molecular Weight:203.197
Hs Code.:
DSSTox Substance ID:DTXSID80559329
Wikidata:Q82442011
Mol file:124281-65-8.mol

Synonyms:124281-65-8;4-methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid;4-Methyl-2-oxo-1H-quinoline-7-carboxylic acid;SCHEMBL5037001;DTXSID80559329;AKOS022647442;SB71390;EN300-213535;4-methyl-2-oxo-1,2-dihydroquinoline-7-carboxylicacid;Z1508949445;7-Quinolinecarboxylicacid,1,2-dihydro-4-methyl-2-oxo-(9CI)

Suppliers and Price of 4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylicAcid
25mg
$ 265.00

AK Scientific
4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylicacid
2.5g
$ 2744.00

AK Scientific
4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylicacid
250mg
$ 766.00

Total 2 raw suppliers

Chemical Property of 4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid

Chemical Property:

PSA：70.42000
LogP:1.94700
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:203.058243149
Heavy Atom Count:15
Complexity:335

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)NC2=C1C=CC(=C2)C(=O)O

Technology Process of 4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid

There total 4 articles about 4-Methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

: 124-38-9,18923-20-1
carbon dioxide

: 89446-51-5
7-bromo-4-methyl-1,2-dihydroquinolin-2-one

: 124281-65-8
4-methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(01)80431-7

Reference yield:

: 61579-06-4
N-(3-bromo-phenyl)-3-oxo-butyramide

: 124281-65-8
4-methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂SO₄

2.1: BuLi / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / -78 °C

With n-butyllithium; sulfuric acid; In tetrahydrofuran; 1.1: Cyclization / 2.1: Metallation / 2.2: Carboxylation;
DOI:10.1039/a800813b

Reference yield:

: 591-19-5
m-Bromoaniline

: 124281-65-8
4-methyl-2-oxo-1,2-dihydroquinoline-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: xylene / Heating

2.1: H₂SO₄

3.1: BuLi / tetrahydrofuran / -78 °C

3.2: tetrahydrofuran / -78 °C

With n-butyllithium; sulfuric acid; In tetrahydrofuran; xylene; 1.1: Acylation / 2.1: Cyclization / 3.1: Metallation / 3.2: Carboxylation;
DOI:10.1039/a800813b