3-Bromo-2-methoxy-5-(trifluoromethyl)pyridine

Base Information

Chemical Name:3-Bromo-2-methoxy-5-(trifluoromethyl)pyridine
CAS No.:124432-63-9
Molecular Formula:C12H14BrNO2
Molecular Weight:256.0199
Hs Code.:2933399090
European Community (EC) Number:871-693-2
DSSTox Substance ID:DTXSID50564546
Wikidata:Q82449278
Mol file:124432-63-9.mol

Synonyms:124432-63-9;3-bromo-2-methoxy-5-(trifluoromethyl)pyridine;3-BROMO-2-METHOXY-5-TRIFLUOROMETHYLPYRIDINE;Pyridine, 3-bromo-2-methoxy-5-(trifluoromethyl)-;MFCD09972202;Methyl(2-Fluorophenyl)acetate;SCHEMBL7916612;AMY8015;DTXSID50564546;AKOS015834035;AB55678;AC-33311;AS-67938;SY066506;CS-0150566;EN300-316311;J-511875

Suppliers and Price of 3-Bromo-2-methoxy-5-(trifluoromethyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Isopropyl 4-bromo-3-methylbenzamide
100mg
$ 305.00

TRC
3-Bromo-2-methoxy-5-trifluoromethylpyridine
1g
$ 75.00

TRC
3-Bromo-2-methoxy-5-trifluoromethylpyridine
250mg
$ 55.00

Sigma-Aldrich
1-(BENZYLOXY)-4-BROMO-2-METHOXYBENZENE AldrichCPR
5MG
$ 115.00

Rieke Metals
4-bromo-2-isopropoxy-1-methoxybenzene
1g
$ 661.00

Rieke Metals
1-bromo-2-(ethoxymethyl)benzene
1g
$ 661.00

Rieke Metals
4-bromo-2-ethoxy-1-methoxybenzene
1g
$ 661.00

Rieke Metals
4-bromo-2-ethoxy-1-methoxybenzene
5g
$ 1328.00

Rieke Metals
1-bromo-2-(ethoxymethyl)benzene
5g
$ 1328.00

Rieke Metals
4-bromo-2-isopropoxy-1-methoxybenzene
5g
$ 1328.00

Total 43 raw suppliers

Chemical Property of 3-Bromo-2-methoxy-5-(trifluoromethyl)pyridine

Chemical Property:

Vapor Pressure:0.557mmHg at 25°C
Melting Point:45-46 °C
Refractive Index:1.47
Boiling Point:196.5 °C at 760 mmHg
PKA:-1.38±0.20(Predicted)
Flash Point:72.7 °C
PSA：22.12000
Density:1.637 g/cm³
LogP:2.87150
Storage Temp.:Keep Cold
Solubility.:Dichloromethane; Ethyl Acetate; Methanol
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:254.95066
Heavy Atom Count:13
Complexity:176

Purity/Quality:

99% ^*data from raw suppliers

N-Isopropyl 4-bromo-3-methylbenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=N1)C(F)(F)F)Br
Uses 1-(Benzyloxy)-4-bromo-2-methoxybenzene is an intermediate in synthesizing 4'',6-Dihydroxy-3'',5-dimethoxy-[1,1''-biphenyl]-3-carboxaldehyde (D452775). It is one of the taste compounds in cured vanilla beans.

Technology Process of 3-Bromo-2-methoxy-5-(trifluoromethyl)pyridine

There total 3 articles about 3-Bromo-2-methoxy-5-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.7%

: 175277-45-9
2-methoxy-5-(trifluoromethyl)pyridine

: 124432-63-9
3-bromo-2-methoxy-5-(trifluoromethyl)pyridine

Guidance literature:: In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 71701-92-3
2-chloro-3-bromo-5-(trifluoromethyl)pyridine

: 124432-63-9
3-bromo-2-methoxy-5-(trifluoromethyl)pyridine

Guidance literature:: With sodium methylate; In methanol;

Reference yield:

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 124432-63-9
3-bromo-2-methoxy-5-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 6 h / 0 - 20 °C / Inert atmosphere

2: acetonitrile / 0 - 20 °C / Inert atmosphere

In methanol; acetonitrile;