4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL

Base Information

• Chemical Name: 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL
• CAS No.: 5452-46-0
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Hs Code.: 2909499000
• Mol file: 5452-46-0.mol

Synonyms:3-Buten-1-ol,1-(3,4-dimethoxyphenyl)- (8CI); Benzenemethanol, 3,4-dimethoxy-a-2-propenyl- (9CI); NSC 18929;Veratryl alcohol, a-allyl-

Chemical Property of 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL

Chemical Property:

• Vapor Pressure: 0.000114mmHg at 25°C
• Melting Point: 94 - 95 °C
• Boiling Point: 322.5°C at 760 mmHg
• Flash Point: 148.9°C
• PSA: 38.69000
• Density: 1.059g/cm³
• LogP: 2.31330

Purity/Quality:

99%min ^*data from raw suppliers

4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL

There total 12 articles about 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + allyl bromide (106-95-6) → 1-(3,4-dimethoxy-phenyl)-but-3-en-1-ol (97387-80-9,5452-46-0)

Guidance literature:

With silver(I) bromide; manganese; In tetrahydrofuran; at 20 ℃; for 20h; Darkness;

DOI:10.1002/ejoc.200800898

Reference yield: 95.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + allylmagnesium bromide (1730-25-2) → 1-(3,4-dimethoxy-phenyl)-but-3-en-1-ol (97387-80-9,5452-46-0)

Guidance literature:

In diethyl ether; for 0.333333h; Heating;

Reference yield: 75.0%

allyltributylstanane (24850-33-7) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 1-(3,4-dimethoxy-phenyl)-but-3-en-1-ol (97387-80-9,5452-46-0)

Guidance literature:

With benzoic acid; scandium tris(trifluoromethanesulfonate); In various solvent(s); at 20 ℃; for 3h;

DOI:10.1055/s-2003-44977

upstream raw materials:

allylmagnesium bromide

3,4-dimethoxy-benzaldehyde

allylmagnesium bromide

3-(4-hydroxyphenyl)propionic acid methyl ester

Downstream raw materials:

(+/-)-3c-(3.4-dimethoxy-phenyl)-cyclohexene-⁽⁴⁾-dicarboxylic acid-(1r.2c)

N-<1-(3,4-dimethoxyphenyl)but-3-en-1-yl>glutarimide

1-(3,4-dimethoxyphenyl)-2-oxiranylethanol

2-[2-(3,4-dimethoxyphenyl)-2-(prop-2-ynyloxy)ethyl]oxirane

Refernces

• 1、 Apolinar, Omar,Derosa, Joseph,Engle, Keary M.,Karunananda, Malkanthi K.,Kleinmans, Roman,Li, Zi-Qi,Tran, Van T.,Wisniewski, Steven R.. "Ni-Catalyzed 1,2-Diarylation of Alkenyl Ketones: A Comparative Study of Carbonyl-Directed Reaction Systems". supporting information. p. 5311 - 5316. Retrieved 2021/07/26.
• 2、 Chen, Mingjie,Li, Wenbo,Wang, Lei,Wang, Yuzhuo,Zhang, Junliang,Zhang, Kenan. "Enantioselective Synthesis of Isoxazolines Enabled by Palladium-Catalyzed Carboetherification of Alkenyl Oximes". supporting information. p. 4421 - 4427. Retrieved 2020/02/11.