5-Bromo-2-benzyloxy-6-methylpyridine

Base Information

• Chemical Name: 5-Bromo-2-benzyloxy-6-methylpyridine
• CAS No.: 126717-60-0
• Molecular Formula: C13H12 Br N O
• Molecular Weight: 278.148
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50563271
• Wikidata: Q82447667
• Mol file: 126717-60-0.mol

Synonyms:126717-60-0;5-Bromo-2-benzyloxy-6-methylpyridine;6-(benzyloxy)-3-bromo-2-methylpyridine;2-BENZYLOXY-5-BROMO-6-METHYLPYRIDINE;6-Benzyloxy-3-bromo-2-picoline;3-bromo-2-methyl-6-phenylmethoxypyridine;Pyridine, 3-bromo-2-methyl-6-(phenylmethoxy)-;MFCD12406109;SCHEMBL15515593;AMY7958;DTXSID50563271;RBXCAMWLXQQRPW-UHFFFAOYSA-N;AKOS015834682;DS-0623;AC-33340;SY067413;CS-0067936;A889379;W-205257

Chemical Property of 5-Bromo-2-benzyloxy-6-methylpyridine

Chemical Property:

• Refractive Index: 1.596
• PSA: 22.12000
• LogP: 3.73150
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 277.01023
• Heavy Atom Count: 16
• Complexity: 206

Purity/Quality:

98% ^*data from raw suppliers

6-(Benzyloxy)-3-bromo-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)OCC2=CC=CC=C2)Br

Technology Process of 5-Bromo-2-benzyloxy-6-methylpyridine

There total 1 articles about 5-Bromo-2-benzyloxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-6-methyl-1,2-dihydropyridin-2-one (54923-31-8) + benzyl bromide (100-39-0) → 6-(benzyloxy)-3-bromo-2-methylpyridine (126717-60-0)

Guidance literature:

With silver carbonate; In benzene; at 40 - 50 ℃; for 24h;

DOI:10.3987/COM-89-5142

Reference yield: 100.0%

6-(benzyloxy)-3-bromo-2-methylpyridine (126717-60-0) + tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → tert-butyl 6-(benzyloxy)-2-methyl-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 15h;

DOI:10.1248/cpb.c19-00800

Reference yield: 94.0%

2-chloro-5-methoxyaniline (2401-24-3) + 6-(benzyloxy)-3-bromo-2-methylpyridine (126717-60-0) → 6-(benzyloxy)-N-(2-chloro-5-methoxyphenyl)-2-methylpyridin-3-amine

Guidance literature:

With 2-(dicyclohexylphosphino)-2',4',6'-tri-1-propyl-1,1'-biphenyl; palladium diacetate; caesium carbonate; In toluene; at 100 ℃; for 15h; Microwave irradiation; Inert atmosphere;

upstream raw materials:

5-bromo-6-methyl-1,2-dihydropyridin-2-one

benzyl bromide

Downstream raw materials:

6-benzyloxy-2-methyl-3,4'-bipyridine

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