3-[(1H-PYRROLE-2-CARBONYL)-AMINO]PROPIONIC ACID

Base Information

• Chemical Name: 3-[(1H-PYRROLE-2-CARBONYL)-AMINO]PROPIONIC ACID
• CAS No.: 129053-84-5
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.179
• Hs Code.: 2933990090
• Mol file: 129053-84-5.mol

Synonyms:b-Alanine,N-(2,3,4,5-tetradehydroprolyl)-

Chemical Property of 3-[(1H-PYRROLE-2-CARBONYL)-AMINO]PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 557.1°Cat760mmHg
• Flash Point: 290.7°C
• PSA: 82.19000
• Density: 1.342g/cm³
• LogP: 0.61010

Purity/Quality:

98% ^*data from raw suppliers

3-(1H-Pyrrole-2-carboxamido)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(1H-PYRROLE-2-CARBONYL)-AMINO]PROPIONIC ACID

There total 6 articles about 3-[(1H-PYRROLE-2-CARBONYL)-AMINO]PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-[(1H-pyrrole-2-carbonyl)-amino]-propionic acid ethyl ester (129053-83-4) → 3-<(1H-pyrrole-2-carbonyl)amino>propionic acid (129053-84-5)

Guidance literature:

With sodium hydroxide; at 60 - 70 ℃; for 1h;

DOI:10.1071/CH9900355

Reference yield: 84.0%

benzyl 3-(2-pyrrolecarboxamido)propionate (136975-50-3) → 3-<(1H-pyrrole-2-carbonyl)amino>propionic acid (129053-84-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 4h;

DOI:10.1248/cpb.47.246

Reference yield: 71.0%

methyl 3-<(1H-pyrrole-2-carbonyl)amino>propionate (161200-30-2) → 3-<(1H-pyrrole-2-carbonyl)amino>propionic acid (129053-84-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.bioorg.2022.105706

upstream raw materials:

3-[(1H-pyrrole-2-carbonyl)-amino]-propionic acid ethyl ester

methyl 3-<(1H-pyrrole-2-carbonyl)amino>propionate

benzyl 3-(2-pyrrolecarboxamido)propionate

pyrrol-2-yl trichloromethyl ketone

Downstream raw materials:

aldisin

C₁₅H₁₄N₂O₂

C₂₁H₁₈N₂O₂

C₁₅H₁₆N₂O₂

Refernces

• 1、 Akunuri, Ravikumar,Veerareddy, Vaishnavi,Kaul, Grace,Akhir, Abdul,Unnissa, Tanveer,Parupalli, Ramulu,Madhavi,Chopra, Sidharth,Nanduri, Srinivas. "Synthesis and antibacterial evaluation of (E)-1-(1H-indol-3-yl) ethanone O-benzyl oxime derivatives against MRSA and VRSA strains". supporting information. . Retrieved 2021/08/27.
• 2、 Xie, Jianwei,Tian, Jinying,Su, Li,Huang, Manna,Zhu, Xinhai,Ye, Fei,Wan, Yiqian. "Pyrrolo[2,3-c]azepine derivatives: A new class of potent protein tyrosine phosphatase 1B inhibitors". supporting information; scheme or table. p. 4306 - 4309. Retrieved 2011/08/10.