Trans-4-hydroxy-N-triphenylmethyl-L-proline methyl ester

Base Information

Chemical Name:Trans-4-hydroxy-N-triphenylmethyl-L-proline methyl ester
CAS No.:129430-93-9
Molecular Formula:C25H25 N O3
Molecular Weight:387.478
Hs Code.:
DSSTox Substance ID:DTXSID10579712
Wikidata:Q82470322
Mol file:129430-93-9.mol

Synonyms:Trans-4-hydroxy-N-triphenylmethyl-L-proline methyl ester;129430-93-9;methyl (2S,4R)-4-hydroxy-1-tritylpyrrolidine-2-carboxylate;DTXSID10579712;AKOS015961826;AC-15019;(4r)-N-trityl-4-hydroxyproline methyl ester;Methyl (4R)-4-hydroxy-1-(triphenylmethyl)-L-prolinate

Suppliers and Price of Trans-4-hydroxy-N-triphenylmethyl-L-proline methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(2S,4S)-Methyl4-hydroxy-1-tritylpyrrolidine-2-carboxylate 95+%
1g
$ 1439.00

American Custom Chemicals Corporation
TRANS-4-HYDROXY-N-TRIPHENYLMETHYL-L-PROLINE METHYL ESTER 95.00%
100MG
$ 525.00

Alichem
(2S,4S)-Methyl4-hydroxy-1-tritylpyrrolidine-2-carboxylate
1g
$ 1464.50

Total 3 raw suppliers

Chemical Property of Trans-4-hydroxy-N-triphenylmethyl-L-proline methyl ester

Chemical Property:

Vapor Pressure:5.82E-11mmHg at 25°C
Refractive Index:1.618
Boiling Point:503.6°C at 760 mmHg
Flash Point:258.3°C
PSA：49.77000
Density:1.211g/cm³
LogP:3.52460
Storage Temp.:2-8°C
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:387.18344366
Heavy Atom Count:29
Complexity:487

Purity/Quality:

99% ^*data from raw suppliers

(2S,4S)-Methyl4-hydroxy-1-tritylpyrrolidine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CC(CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)O
Isomeric SMILES:COC(=O)[C@@H]1C[C@H](CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)O

Technology Process of Trans-4-hydroxy-N-triphenylmethyl-L-proline methyl ester

There total 12 articles about Trans-4-hydroxy-N-triphenylmethyl-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 67-56-1
methanol

: 124456-35-5
5-triphenylmethyl-2-oxa-5-aza-bicyclo<2.2.1>heptan-3-one

: 129430-93-9
(2S,4S)-methyl 4-hydroxy-1-tritylpyrrolidine-2-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 48h; Ambient temperature;

Reference yield: 76.0%

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 76-83-5
trityl chloride

: 129430-93-9,129430-94-0
methyl (2S,4R)-4-hydroxy-1-tritylpyrrolidine-2-carboxylate

Guidance literature:: With triethylamine; In chloroform; at 0 ℃;
DOI:10.1016/S0040-4039(97)10793-6

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 76-83-5
trityl chloride

: 129430-93-9
(2S,4S)-methyl 4-hydroxy-1-tritylpyrrolidine-2-carboxylate

Guidance literature:: L-4-hydroxyproline methyl ester hydrochloride; trityl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

With benzoic acid; 1,2-bis-(diphenylphosphino)ethane; diethylazodicarboxylate; In toluene; at 20 ℃; for 2h;

With potassium hydroxide; In methanol; for 2h;
DOI:10.1016/j.tetlet.2003.08.075