4-Pyrrolidin-2-ylpyridine

Base Information

• Chemical Name: 4-Pyrrolidin-2-ylpyridine
• CAS No.: 130343-15-6
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.208
• Hs Code.: 2933990090
• European Community (EC) Number: 696-435-4
• DSSTox Substance ID: DTXSID50378004,DTXSID901305418
• Nikkaji Number: J1.712.397A
• Mol file: 130343-15-6.mol

Synonyms:4-pyrrolidin-2-ylpyridine;128562-25-4;4-(2-pyrrolidinyl)pyridine;4-(pyrrolidin-2-yl)pyridine;4-Pyrrolidin-2-Yl-Pyridine;2-(4-Pyridyl)pyrrolidine;130343-15-6;PYRIDINE, 4-(2-PYRROLIDINYL)-;Pyridine, 4-(2-pyrrolidinyl)-, (+)- (9CI);Pyridine, 4-(2-pyrrolidinyl)-, (-)- (9CI);130343-14-5;MFCD01862536;4-((2S)PYRROLIDIN-2-YL)PYRIDINE;(R)-4-Pyrrolidin-2-yl-pyridine;(S)-4-Pyrrolidin-2-yl-pyridine;1197239-21-6;(+/-)-4-(Pyrrolidin-2-yl)pyridine;SCHEMBL168915;AMY5558;DTXSID50378004;GDGNPIOGJLCICG-UHFFFAOYSA-N;(-)-4-(2-Pyrrolidinyl)pyridine;4-(2-Pyrrolidinyl)pyridine,96%;DTXSID901305418;rac.-2-(pyridin-4-yl)pyrrolidine;(RS)-4-(2-pyrrolidinyl)-pyridine;AR1070;BBL020548;STK893237;AKOS001378684;AKOS016343657;4-pyrrolidin-2-ylpyridine, AldrichCPR;AB49753;AB49756;CS-W002850;PS-3581;SB32686;SB32687;AC-24298;SY005586;BB 0249475;FT-0643093;FT-0694674;EN300-27335;A26474;W-205324;4-(2-Pyrrolidinyl)pyridine;Z238920298;66269-97-4

Chemical Property of 4-Pyrrolidin-2-ylpyridine

Chemical Property:

• Refractive Index: 1.536
• Boiling Point: 253.8°Cat760mmHg
• Flash Point: 107.3°C
• PSA: 24.92000
• Density: 1.042g/cm³
• LogP: 1.83490
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.100048391
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

98%min ^*data from raw suppliers

(R)-4-(Pyrrolidin-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)C2=CC=NC=C2

Technology Process of 4-Pyrrolidin-2-ylpyridine

There total 4 articles about 4-Pyrrolidin-2-ylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C13H17N3 → 4-(pyrrolidin-2-yl)pyridine (66269-75-8,128562-25-4,130343-14-5,130343-15-6)

Guidance literature:

With trifluoroacetic acid; hydrazine; In ethanol; at 120 ℃; for 1h;

DOI:10.1021/ja072577n

Reference yield:

4-(3,4-dihydro-2H-pyrrol-5-yl)pyridine (66269-78-1) → 4-(pyrrolidin-2-yl)pyridine (66269-75-8,128562-25-4,130343-14-5,130343-15-6)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In methanol;

DOI:10.1021/ja017774f

Reference yield:

isonicotinic acid ethylester (1570-45-2) → 4-(pyrrolidin-2-yl)pyridine (66269-75-8,128562-25-4,130343-14-5,130343-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran

1.2: HCl

1.3: NaOH

2.1: NaBH₄; AcOH / methanol

With sodium tetrahydroborate; sodium hydride; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1021/ja017774f

upstream raw materials:

4-(3,4-dihydro-2H-pyrrol-5-yl)pyridine

isonicotinic acid ethylester

Downstream raw materials:

1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine