S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR

Base Information

• Chemical Name: S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR
• CAS No.: 130383-75-4
• Molecular Formula: C₁₅H₂₁IN₂O₃
• Molecular Weight: 404.248
• Mol file: 130383-75-4.mol

Synonyms:S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR

Chemical Property of S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR

Chemical Property:

• PSA: 61.80000
• LogP: 2.54830
• Storage Temp.: 2-8°C
• Solubility.: H2O: <0.5 mg/mL, slightly soluble

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR

There total 14 articles about S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

FLA 981 → [123I]-IBZM (84226-06-2,130383-75-4)

Guidance literature:

With Iodine monochloride; In methanol; dichloromethane; at 50 ℃; for 2h;

Reference yield: 73.0%

N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide (96897-88-0) → [123I]-IBZM (84226-06-2,130383-75-4) + 5-Iodo-BZM (132448-74-9)

Guidance literature:

With hydrogenchloride; boron tribromide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm00147a025

Reference yield: 71.0%

(-)-BZM (84226-04-0) → [123I]-IBZM (84226-06-2,130383-75-4)

Guidance literature:

(-)-BZM; With tetrafluoroboric acid; In ethanol; water; at 20 ℃; for 0.5h;

With N-iodo-succinimide; silver(I) triflimide; In dichloromethane; at 20 ℃; for 0.8h; Darkness;

DOI:10.1021/acs.joc.5b02761

upstream raw materials:

N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide

(S)-2-(Aminomethyl)-1-ethylpyrrolidine

2-hydroxy-6-methoxybenzoic acid

2-6-dimethoxybenzoic acid

Refernces

• 1、 Racys, Daugirdas T.,Warrilow, Catherine E.,Pimlott, Sally L.,Sutherland, Andrew. "Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide". supporting information. p. 4782 - 4785. Retrieved 2015/10/12.
• 2、 Kung,Kasliwal,Pan,Kung,Mach,Guo. "Dopamine D-2 receptor imaging radiopharmaceuticals: Synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6 methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide". . p. 1039 - 1043. Retrieved 2007/10/02.