4'-ETHYL-3'-METHYLACETANILIDE

Base Information

• Chemical Name: 4'-ETHYL-3'-METHYLACETANILIDE
• CAS No.: 7149-81-7
• Molecular Formula: C11H15 N O
• Molecular Weight: 177.246
• Mol file: 7149-81-7.mol

Synonyms:m-Acetotoluidide,4'-ethyl- (6CI); 3-Methyl-4-ethyl-N-acetylaniline; NSC 72335

Chemical Property of 4'-ETHYL-3'-METHYLACETANILIDE

Chemical Property:

• Melting Point: 89-91oC(lit.)
• Boiling Point: 328.0±21.0 °C(Predicted)
• PKA: 15.13±0.70(Predicted)
• Flash Point: 193.8oC
• PSA: 29.10000
• Density: 1.032±0.06 g/cm3(Predicted)
• LogP: 2.58880

Purity/Quality:

97% ^*data from raw suppliers

4'-ETHYL-3'-METHYLACETANILIDE 99.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-ETHYL-3'-METHYLACETANILIDE

There total 4 articles about 4'-ETHYL-3'-METHYLACETANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-bromo-3-methylacetanilide (90914-81-1) + diethylzinc (557-20-0) → acetic acid-(4-ethyl-3-methyl-anilide) (7149-81-7)

Guidance literature:

4-bromo-3-methylacetanilide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; for 0.333333h; Inert atmosphere;

diethylzinc; In 1,4-dioxane; hexane; at 20 - 80 ℃; for 2.25h; Inert atmosphere;

Reference yield: 71.0%

Ethyl boronic acid (4433-63-0) + 4-bromo-3-methylacetanilide (90914-81-1) → acetic acid-(4-ethyl-3-methyl-anilide) (7149-81-7)

Guidance literature:

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

1-amino-3-methylbenzene (108-44-1) → acetic acid-(4-ethyl-3-methyl-anilide) (7149-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc chloride / 280 °C

With zinc(II) chloride;

DOI:10.1039/jr9340000418

upstream raw materials:

4-ethyl-3-methylaniline

1-amino-3-methylbenzene

Ethyl boronic acid

4-bromo-3-methylacetanilide

Downstream raw materials:

2'-bromo-4'-ethyl-5'-methylacetanilide

acetic acid-(3-ethyl-4-methyl-anilide)

4-ethyl-5-methyl-2-nitro-aniline

acetic acid-(4-ethyl-5-methyl-2-nitro-anilide)

Refernces