2-BROMO-5-AMINOMETHYL-THIAZOLE HYDROCHLORIDE

Base Information

• Chemical Name: 2-BROMO-5-AMINOMETHYL-THIAZOLE HYDROCHLORIDE
• CAS No.: 131748-92-0
• Molecular Formula: C₄H₅BrN₂S
• Molecular Weight: 193.067
• Hs Code.: 2934100090
• Mol file: 131748-92-0.mol

Synonyms:2-BROMO-5-AMINOMETHYL-THIAZOLE HYDROCHLORIDE

Chemical Property of 2-BROMO-5-AMINOMETHYL-THIAZOLE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 263.9±15.0 °C(Predicted)
• PKA: 7?+-.0.29(Predicted)
• PSA: 67.15000
• Density: 1.782±0.06 g/cm3(Predicted)
• LogP: 2.86660

Purity/Quality:

95% Min ^*data from raw suppliers

(2-Bromo-1,3-thiazol-5-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2-Bromo-1,3-thiazol-5-yl)methanamine is a useful reagent for the preparation of CK2 inhibitors used in the treatment of cancer.

Technology Process of 2-BROMO-5-AMINOMETHYL-THIAZOLE HYDROCHLORIDE

There total 2 articles about 2-BROMO-5-AMINOMETHYL-THIAZOLE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5-(bromomethyl)-1,3-thiazole (131748-91-9) → 2-bromo-5-thiazolylmethylamine (131748-92-0)

Guidance literature:

With potassium phtalimide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

C12H7BrN2O2S (917946-67-9) → 2-bromo-5-thiazolylmethylamine (131748-92-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1021/jf072851x

Reference yield:

2-bromo-5-thiazolylmethylamine (131748-92-0) + ethanol (64-17-5) → C6H10N2OS (937662-94-7)

Guidance literature:

ethanol; With sodium; Reflux;

2-bromo-5-thiazolylmethylamine; In ethanol; Reflux;

DOI:10.1021/jf072851x

upstream raw materials:

C₁₂H₇BrN₂O₂S

2-bromo-5-(bromomethyl)-1,3-thiazole

Downstream raw materials:

C₆H₁₀N₂OS

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