Z-1,2-TRANS-ACHC-OH

Base Information

• Chemical Name: Z-1,2-TRANS-ACHC-OH
• CAS No.: 61935-48-6
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Hs Code.: 2924299090
• Mol file: 61935-48-6.mol

Synonyms:TRANS-1-(BENZYLOXYCARBONYL-AMINO)-CYCLOHEXYL-2-CARBOXYLIC ACID;TRANS-2-BENZYLOXYCARBONYLAMINOCYCLOHEXANECARBOXYLIC ACID;Z-TRANS-2-AMINOCYCLOHEXANECARBOXYLIC ACID;Z-1,2-TRANS-ACHC-OH;Cyclohexanecarboxylic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, (1R,2R)-rel- (9CI)

Chemical Property of Z-1,2-TRANS-ACHC-OH

Chemical Property:

• Melting Point: 146-148 °C(Solv: methanol (67-56-1))
• Boiling Point: 484.7±44.0 °C(Predicted)
• PKA: 4.94±0.28(Predicted)
• PSA: 75.63000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 2.94710

Purity/Quality:

98%Min ^*data from raw suppliers

Z-trans-2-aminocyclohexanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-1,2-TRANS-ACHC-OH

There total 1 articles about Z-1,2-TRANS-ACHC-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-2-amino-1-cyclohexanecarboxylic acid (5691-19-0) + benzyl chloroformate (501-53-1,94274-21-2) → trans-2-(benzyloxycarbonylamino)cyclohexanecarboxylic acid (61935-48-6)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 2.) 4 h;

Reference yield: 79.0%

trans-2-(benzyloxycarbonylamino)cyclohexanecarboxylic acid (61935-48-6) + methyl iodide (74-88-4) → methyl trans-2-<(benzyloxycarbonyl)methylamino>cyclohexanecarboxylate (132724-04-0)

Guidance literature:

With silver(l) oxide; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield: 38.0%

trans-2-(benzyloxycarbonylamino)cyclohexanecarboxylic acid (61935-48-6) + isopropylamine (75-31-0) → trans-N-isopropyl-2-(benzyloxycarbonylamino)cyclohexanecarboxamide

Guidance literature:

trans-2-(benzyloxycarbonylamino)cyclohexanecarboxylic acid; With chloroformic acid ethyl ester; triethylamine; In toluene; for 0.25h;

isopropylamine; In dichloromethane; toluene; Further stages.;

DOI:10.1021/jo020070j

upstream raw materials:

trans-2-amino-1-cyclohexanecarboxylic acid

benzyl chloroformate

Downstream raw materials:

trans-2-(benzyloxycarbonylamino)cyclohexanecarboxamide

trans-2-(benzyloxycarbonylamino)-N-methylcyclohexanecarboxamide

methyl trans-2-<(benzyloxycarbonyl)methylamino>cyclohexanecarboxylate

{2-[((1R,2R)-2-Amino-cyclohexanecarbonyl)-amino]-acetylamino}-acetic acid ethyl ester

Refernces

• 1、 Wang, Yan,Jia, Shaojuan,Tseng, Ben,Drewe, John,Cai, Sui Xiong. "Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids". . p. 6178 - 6182. Retrieved 2008/04/02.
• 2、 Goendoes, Gyoergy,Gera, Lajos,Wittmann, Gyula,Balaspiri, Lajos,Kovacs, Kalman. "SYNTHESIS OF NEW PROSTAGLANDIN-LIKE CARBOXAMIDES. (PRELIMINARY COMMUNICATION)". . p. 187 - 190. Retrieved 2007/10/02.