2-(Morpholin-2-yl)ethanol

Base Information

• Chemical Name: 2-(Morpholin-2-yl)ethanol
• CAS No.: 132995-76-7
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• European Community (EC) Number: 696-405-0
• DSSTox Substance ID: DTXSID70927891
• Mol file: 132995-76-7.mol

Synonyms:132995-76-7;2-(Morpholin-2-yl)ethanol;2-(2-Hydroxyethyl)morpholine;2-morpholin-2-ylethanol;2-Morpholin-2-yl-ethanol;2-Morpholineethanol;2-(morpholin-2-yl)ethan-1-ol;2-(2-Morpholinyl)ethanol;SCHEMBL49736;DTXSID70927891;OJZYVZNGKDTSFP-UHFFFAOYSA-N;MFCD09608099;AKOS006281228;SB21515;2-(2-hydroxyethyl)morpholine, AldrichCPR;AS-47369;CS-0307946;EN300-102007;F13466;A888233

Chemical Property of 2-(Morpholin-2-yl)ethanol

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.445
• Boiling Point: 235.3°Cat760mmHg
• PKA: 14.87±0.10(Predicted)
• Flash Point: 96.1°C
• PSA: 41.49000
• Density: 1.019g/cm³
• LogP: -0.31400
• Storage Temp.: 2-8°C
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 77.5

Purity/Quality:

97% ^*data from raw suppliers

2-Morpholin-2-Yl-Ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)CCO

Technology Process of 2-(Morpholin-2-yl)ethanol

There total 3 articles about 2-(Morpholin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-hydroxyethyl)-4-benzylmorpholine (112887-43-1) → (2-hydroxyethyl)-morpholine (132995-76-7)

Guidance literature:

palladium; In methanol;

Reference yield:

(±)-ethyl 2-(morpholin-2-yl)acetate (503601-25-0) → (2-hydroxyethyl)-morpholine (132995-76-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 23 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm200733r

Reference yield:

ethyl 4-(phenylmethyl)-2-morpholineacetate (73933-19-4) → (2-hydroxyethyl)-morpholine (132995-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate / ethanol / 3 h / 23 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 23 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; ammonium formate; In diethyl ether; ethanol;

DOI:10.1021/jm200733r

upstream raw materials:

2-(2-hydroxyethyl)-4-benzylmorpholine

ethyl 4-(phenylmethyl)-2-morpholineacetate

(±)-ethyl 2-(morpholin-2-yl)acetate

Downstream raw materials:

WYE-114152

1-(3-methoxyphenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

1-(4-fluorophenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

1-(2,4-difluorophenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide