WYE-114152

Base Information

• Chemical Name: WYE-114152
• CAS No.: 1033219-23-6
• Molecular Formula: C₁₈H₂₀FN₃O₃S
• Molecular Weight: 377.44
• Mol file: 1033219-23-6.mol

Synonyms:

Chemical Property of WYE-114152

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of WYE-114152

There total 5 articles about WYE-114152 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(±)-tert-butyl 2-(2-hydroxyethyl)morpholine-4-carboxylate (913642-78-1,1257856-15-7,136992-21-7) → WYE-114152 (1033219-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1021/jm200733r

Reference yield:

C23H28FN3O5S → WYE-114152 (1033219-23-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm200733r

Reference yield:

(2-hydroxyethyl)-morpholine (132995-76-7) → WYE-114152 (1033219-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / diethyl ether; dichloromethane; water; ethyl acetate / 18 h / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane; dichloromethane

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate; 2: Mitsunobu reaction;

DOI:10.1021/jm200733r

upstream raw materials:

(±)-tert-butyl 2-(2-hydroxyethyl)morpholine-4-carboxylate

ethyl 4-(phenylmethyl)-2-morpholineacetate

(2-hydroxyethyl)-morpholine

(±)-ethyl 2-(morpholin-2-yl)acetate