1-Piperidinecarboxylic acid, 2-(2-propen-1-yl)-, methyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 2-(2-propen-1-yl)-, methyl ester
• CAS No.: 133127-73-8
• Molecular Formula: C10H17NO2
• Molecular Weight: 183.25
• Mol file: 133127-73-8.mol

Synonyms:1-Piperidinecarboxylic acid, 2-(2-propen-1-yl)-, methyl ester

Chemical Property of 1-Piperidinecarboxylic acid, 2-(2-propen-1-yl)-, methyl ester

Chemical Property:

• Boiling Point: 94 - 98 °C (3 mmHg)
• PSA: 29.54000
• LogP: 2.12130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 2-(2-propen-1-yl)-, methyl ester

There total 10 articles about 1-Piperidinecarboxylic acid, 2-(2-propen-1-yl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-methoxy-piperidine-1-carboxylic acid methyl ester (56475-86-6) + allyl-trimethyl-silane (762-72-1) → methyl 2-(2-propenyl)piperidinecarboxylate (133127-73-8)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -30 - 0 ℃;

DOI:10.1016/j.tetasy.2004.09.022

Reference yield: 67.0%

(+/-)-[(N-methoxycarbonyl)piperidine]-2-carboxylic acid (134902-40-2) + allyl-trimethyl-silane (762-72-1) → methyl 2-(2-propenyl)piperidinecarboxylate (133127-73-8)

Guidance literature:

(+/-)-[(N-methoxycarbonyl)piperidine]-2-carboxylic acid; With [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; at 20 ℃; for 3h;

allyl-trimethyl-silane; With boron trifluoride diethyl etherate; at 0 - 20 ℃; for 3h;

DOI:10.1016/S0040-4039(00)00306-3

Reference yield: 64.0%

piperidine-1-carboxylic acid methyl ester (1796-27-6) + allyl-trimethyl-silane (762-72-1) → methyl 2-(2-propenyl)piperidinecarboxylate (133127-73-8)

Guidance literature:

piperidine-1-carboxylic acid methyl ester; In dichloromethane; at -72 ℃; graphite felt anode;

allyl-trimethyl-silane; In dichloromethane; at -28 ℃;

DOI:10.1021/ja9920112

upstream raw materials:

2-methoxy-piperidine-1-carboxylic acid methyl ester

allyl-trimethyl-silane

α-allyl-α-cyano-N-methoxycarbonylpiperidine

2-tert-Butylperoxy-piperidine-1-carboxylic acid methyl ester

Downstream raw materials:

trans-5-hydroxy-2-propylpiperidine

2-Propyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Refernces

• 1、 Asami, Ryosuke,Fuchigami, Toshio,Atobe, Mahito. "Development of an anodic substitution reaction system using acoustic emulsification". . p. 244 - 246. Retrieved 2008.
• 2、 Asami, Ryosuke,Fuchigami, Toshio,Atobe, Mahito. "A new approach to anodic substitution reaction using acoustic emulsification". . p. 1938 - 1943. Retrieved 2008.
• 3、 Kirira, Peter G.,Kuriyama, Masami,Onomura, Osamu. "Electrochemical deallylation of α-allyl cyclic amines and synthesis of optically active quaternary cyclic amino acids". experimental part. p. 3970 - 3982. Retrieved 2010/07/04.